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MedlinePlus: Neuromuscular Disorders (485 words) |
 | The primary NIH organization for research on Neuromuscular Disorders is the National Institute of Neurological Disorders and Stroke |
| Neuromuscular disorders affect the nerves that control your voluntary muscles. |
| Many neuromuscular diseases are genetic, which means they run in families or there is a mutation in your genes. |
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Neuromuscular Junction Effects (6917 words) |
| Failure of neuromuscular transmission--loss of ability of a signal from a nerve cell to produce contraction in the muscle fiber to which it connects--has been reported with anticholinesterases, but the reasons for this failure are incompletely understood. |
| Transient endplate depolarization was suggested to account for failure of neuromuscular transmission induced by low concentrations of anticholinesterases; while high concentrations induce additional desensitization and direct blockade of the endplate receptor, which becomes the dominant mechanism for failure of neuromuscular transmission (Maselli and Leung, 1993a and 1993b). |
| Effects on the neuromuscular junction (peripheral nicotinic effects) should be compared to and correlated with corresponding peripheral muscarinic effects and central nicotinic or muscarinic effects (determined through in vitro studies and/or by giving PB to rats under stress, or physostigmine to rats without stress). |
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