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Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord.
Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections (about 10 to 20 years after the primary infection), and is a progressive, life-threatening complication.
Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent (hidden) syphilis.