Neurotrophins are a family of molecules that encourage survival of nervous tissue. Neurotrophic factors are secreted by cells in a neuron's target field, and act by prohibiting the neuron from apoptosis. In this way, excess neurons are removed. Jump to: navigation, search Neurons (also spelled neurones or called nerve cells) are the primary cells of the nervous system. ... In biology, apoptosis (from the Greek words apo = from and ptosis = falling, pronounced ap-a-tow-sis[1]) is one of the main types of programmed cell death (PCD). ...
The neurotrophin family include nerve growth factors nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). There are two classes of receptors, p75 and the Tyrosine kinases. p75 is a low affinity neurotrophin receptor, to which all neurotrophins bind. The Tyrosine kinases include TrkA, TrkB, and TrkC, and will only bind with specific neurotrophins, but with a much higher affinity. Nerve growth factor is like any other growth factors like Platlet derived growth factor and fibroblast growth facor is essential for the normal growth of nervous tissues. ... Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor usually derived in the brain. ... Tyrosine kinases are a subclass of protein kinase, see there for the principles of protein phosphorylation A tyrosine kinase (EC 2. ... Tyrosine kinases are a subclass of protein kinase, see there for the principles of protein phosphorylation A tyrosine kinase (EC 2. ...
Neurotrophins are polypeptide growth factors involved in the development and maintenance of neurons, as well as non-neuronal cells.
Neurotrophin signaling occurs via two types of receptors including (a) tyrosine kinase high affinity Trk receptors and (b) the low affinity p75 receptor [20].
Neurotrophin expression by LC cells and ONH astrocytes may be beneficial to RGCs during ischemia, but may be unable to promote the survival of these neurons during reperfusion.
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