Nicolae Creţulescu was a three-time prime minister of Romania, serving 1862-1863, 1865-1866 and in 1867.

He first became prime minister after the assassination of Barbu Catargiu. He avoided debating the issue of agrarian reform, at that time the most contentious subject in Romanian politics, focusing instead on unifying the public health system, creating the Directorate General of the Public Archive, and establishing a Council for Public Instruction. He laid the groundwork for further laws secularizing the property of monasteries.