NTA is the chemical compound nitrilotriacetic acid. NTA is a chelating agent, forming coordination compounds with metal ions (chelates) such as Ca2+, Cu2+ or Fe3+. In 1999 about 20,000 tons of NTA were used in Europe. Chelation (from Greek, claw like) describes the reversible binding of an organic ligand, the chelator or chelating agent, to a metal ion, forming a metal complex, the chelate. ...
The uses of NTA are similar to that of EDTA. EDTA Metal-EDTA chelate This is a computer generated image of EDTAs 3-dimensional structure. ...
In contrast to EDTA, NTA is easily biodegradable and is almost completely removed during wastewater treatment.
Nitrilotriaceticacid is absorbed in mammals, but it is not metabolized and is excreted rapidly by filtration in the kidney.
Nitrilotriaceticacid does not induce developmental toxicity in rats, rabbits or mice exposed during gestation and gave negative results in short-term assays to screen for teratogenesis in two cellular assays in Drosophila larvae and frog embryos.
Nitrilotriaceticacid and its disodium and trisodium salts were not genotoxic in experimental systems in vivo, except that the acid induced aneuploidy in mouse germ cells.
Nitrilotriaceticacid and its sodium salts have been produced since the 1930s for use as metal chelating agents in household and industrial detergents, industrial water treatment, textile preparation and metal finishing.
Exposure to nitrilotriaceticacid, and presumably to its water-soluble metal complexes, occurs as a result of its presence in household detergents and in drinking-water.
Nitrilotriaceticacid, trisodium salt was tested for carcinogenicity in mice and rats by oral administration.