Noscapine (also known as Narcotine) is an opioid agonist without significant analgesic properties [1]. It is grouped as part of the benzylisoquinolines, of which papaverine is also included. This agent is primarily used for its antitussive (cough-suppressing) effects. It has also been shown to have anticancer activity (PDF file). The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. ... Agonists An agonist is a substance that binds to a receptor and triggers a response in the cell. ... An analgesic (colloquially known as a painkiller) is any member of the diverse group of drugs used to relieve pain and to achieve analgesia. ... Papaverine is an opium alkaloid (opiate) used intravenously in the treatment of erectile dysfunction. ... A cough medicine is a drug used to treat coughing and related conditions. ...

Mechanism of action

Noscapine's antitussive effects appear to be primarily mediated by its sigma receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole,a sigma specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine [2]. Opioid receptors are a group of G-protein coupled receptors with opioids as ligands. ... An antagonist is a character or group of characters, or, sometimes an institution of a story who represents the opposition against which the heroes and/or protagonists must contend. ...

Noscapine Abuse

Noscapine(Nospen)has a history of OTC abuse in a several countries being readily available from local pharmacies as a prescription drug. The effects, beginning around 45 to 120 mins after consumption, are similar to dextromethorphan (DXM) and alcohol intoxication.

Effects -Loss of coordination -Hallucinations (auditory and visual) -Loss of sexual drive -Swelling of prostate -Loss of appetite -Dilated pupils -Increased heart rate -Shaking and muscle spasms -Increased alertness -Loss of any sleepiness -Loss of stereoscopic vision

The effects shown above are not permanent, the user may experience spasms the following day after yawning.It is possible to over dose (20+ pills) and avoid taking any other drug in combination to this medication. WARNING: Do not take noscapine if any MAOIs (monoamine oxidase inhibitors), unknown and potentially fatal effects may occur. Marijuana and alcohol are suitable in combination with noscapine. There has been no known allergic reactions to this drug but caution should be excercised as with any other new inebriant. Uh..yeah thats it..I couldn't find any info on this pill being used as a drug anywhere on the internet so i decided to write sumthin.....anyone with any experience with noscapine feel free to edit this. -Kappa