Octavio Zambrano (born February 3, 1958 in Guayaquil, Ecuador) is a soccer coach, one of the all-time winnigest coaches in Major League Soccer history.

Zambrano moved to the United States from his native Ecuador in 1980 to attend Chapman University and later played in the Major Indoor Soccer League. Assistant coaching duties in the APSL and USISL followed. He joined MLS as an assistant for Lothar Osiander with the Los Angeles Galaxy and assumed head coaching duties when Osiander was fired early in the 1997 season. Zambrano's 1998 Galaxy team broke all MLS scoring records, ending the year with 85 goals. But in the playoffs they faltered, falling to Bob Bradley's expansion Chicago Fire. Five games into the 1999 season, Zambrano was fired.

Zambrano re-surfaced as the head coach of the MetroStars in 2000, replacing the woeful Bora Milutinovic. He coached the team for three years, following a promising first year with a weaker second, and a disastorus third. Zambrano was fired and replaced by Bradley after the 2002 season.