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Encyclopedia > Opportunistic infections

Opportunistic infections are infections in immunodeficient patients caused by pathogens which are incapable of causing infection in immunocompetent individuals.


Opportunistic infections occur in immunodeficiency diseases such as AIDS, as well as in patients who are on immunosuppressant drugs to prevent rejection of organ transplants and patients on some forms of chemotherapy.


Opportunistic pathogens include bacteria, viruses, fungi and protozoa. Typical opportunistic infections include Pneumocystis carinii pneumonia, cytomegalovirus infections and aspergillosis. None of these cause significant illness in immunocompetent individuals, but all can be life-threatening in the immunodeficient.


Certain otherwise rare, virally-mediated tumours such as Kaposi's sarcoma could be considered a form of opportunistic infection.


  Results from FactBites:
 
Opportunistic Infections in Immunodeficient Populations (996 words)
Assessments of the prevalence and incidence of opportunistic infections in these areas and comparability of the available data are hampered by limited access to care, diagnostic capabilities, and surveillance data.
The opportunistic infections in these patients originate from endogenous flora (e.g, invasive candidiasis), from the general (nonhospital) environment (e.g, histoplasmosis, TB, disseminated strongyloidiasis), or from the hospital environment (e.g, aspergillosis, legionellosis, and infections with vancomycin-resistant enterococci or multiply resistant gram-negative bacteria).
For example, in bone marrow transplant recipients, infections within 1 month of transplantation (pre-engraftment) occur as a result of neutropenia and disruption of mucosal surfaces; infections that occur in the second or third months are due to deficiencies in cell-mediated immunity and are more frequent in the setting of graft versus host disease.
CCFA.org: opportunistic infections (1711 words)
Opportunistic infections also include infections like herpes and tuberculosis, which affect people with a normal immune system, but which are more severe or occur more frequently in people with a weakened immune system.
Furthermore, opportunistic infections are a frequent cause of relapse or disease flares in IBD patients.
Opportunistic infections in the course of steroid therapy result primarily from prolonged exposure to high doses (greater than prednisone 20 mg/day).
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