The enzyme ornithine decarboxylase (ODC) is a homodimer of 461 amino acids (in humans, at least) that catalyzes the decarboxylation of ornithine producing, as a result, diamine putrescine. This is the first step and the rate limiting step in humans for the production of polyamines, compounds required for cell division. Ornithine Decarboxylase gene expression is induced by a large number of biological stimuli including seizure activity in the brain.[citation needed] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... Short and long arms Chromosome. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... The general structure of an α-amino acid molecule, with the amine group on the left and the carboxyl group on the right. ... It has been suggested that this article or section be merged into Catalysis. ... Ornithine is an amino acid, whose structure is: NH2-CH2-CH2-CH2-CHNH2-COOH Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. ... Putrescine (sometimes spelled putrescin or putrescene) is an organic chemical compound NH2(CH2)4NH2 (1,4-diaminobutane or butanediamine) formed by and having the smell of rotting flesh. ... The polyamines are organic compounds, that have two or more primary amino groups, such as putrescine, spermidine, and spermine, that are growth factors in both eucaryotic and procaryotic cells. ... This does not cite its references or sources. ...
Ornithine decarboxylase is the most well-characterized cellular protein subject to ubiquitin-independent proteasomal degradation. Although most proteins must first be tagged with multiple ubiquitin molecules before they are bound and degraded by the proteasome, ornithine decarboxylase degradation is instead mediated by several recognition sites on the protein and its accessory factor antizyme 1. The ODC degradation process is regulated in a negative feedback loop by its reaction products. [1] Ubiquitin is a very conserved small regulatory protein that is ubiquitous in eukaryotes. ... A proteasome is a barrel-shaped multi-protein complex that can digest other proteins into short polypeptides and amino acids in an ATP-driven reaction. ... Negative feedback is a type of feedback, during which a system responds so as to reverse the direction of change. ...
^ Zhang M, Pickart CM, Coffino P. (2003). Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. EMBO J 22(7):1488-96.
Ornithinedecarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.
BACKGROUND: Previous research suggests that the G315A single-nucleotide polymorphism in the ornithinedecarboxylase (ODC) gene may be a genetic marker for risk of colorectal neoplasia and may also modify the association of aspirin use with risk.
METHODS: We tested these hypotheses among participants in the Aspirin/Folate Polyp Prevention Study who were randomly assigned to placebo or to aspirin treatment (81 or 325 mg daily) and followed for 3 years for the occurrence of new adenomas.
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