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Encyclopedia > Osteopetrosis

Osteopetrosis is an extremely rare inherited disorder whereby the bones harden, becoming denser. Rare is a term used to denote low numbers or abundance. ... Biological inheritance is the process by which an offspring cell or organism acquires or becomes predisposed to characteristics of its parent cell or organism. ... A disease is any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. ... Grays illustration of a human femur, a typically recognized bone. ... In mathematics, the term dense has at least three different meanings. ...


Normally, bone growth is a balance between osteoblasts (cells that create bone tissue) and osteoclasts (cells that destroy bone tissue). Sufferers of osteopetrosis have a deficiency of osteoclasts, meaning too much bone is being created. Mild osteopetrosis may cause no symptoms, and present no problems. However, serious forms can result in stunted growth, deformity, increased likelihood of fractures, and anaemia. It can also result in blindness, facial paralysis, and deafness, due to the increased pressure put on the nerves by the extra bone. In biology growth is increase in size. ... An osteoblast (from the Greek words for bone and to build) is a cell which produces osteoid. ... An osteoclast is a multinucleated cell that degrades and reabsorbs bone. ... In mathematics, a deficient number or defective number is a number n for which σ(n) < 2n. ... A fractured bone in a living person is treated by immobilization with a plaster or fiberglass cast, and in some cases surgical nails, screws, plates and wires to supplement a cast. ... This article discusses the medical condition. ... Blindness can be defined physiologically as the condition of lacking sight. ... Paralysis is the complete loss of muscle function for one or more muscle groups. ... This article is about hearing impairment in the patholocial sense. ... A nerve is an enclosed, cable-like bundle of nerve fibers or axons, which includes the glia that ensheath the axons in myelin. ...


There is no cure, although bone marrow transplants are being tested. It is believed the healthy marrow will provide the sufferer with cells from which osteoclasts will develop. Bone marrow is the tissue comprising the center of large bones. ... An organ transplant is the transplantation of an organ (or part of one) from one body to another, for the purpose of replacing the recipients damaged or failing organ with a working one from the donor. ...


  Results from FactBites:
 
Osteopetrosis - Wikipedia, the free encyclopedia (174 words)
Osteopetrosis is an extremely rare inherited disorder whereby the bones harden, becoming denser.
Normally, bone growth is a balance between osteoblasts (cells that create bone tissue) and osteoclasts (cells that destroy bone tissue).
Sufferers of osteopetrosis have a deficiency of osteoclasts, meaning too much bone is being created.
Paget Foundation_Q&A (1760 words)
In osteopetrosis the cells that break down bone, the osteoclasts, usually are fewer in number or are ineffective in removing bone.
Malignant infantile osteopetrosis is inherited as an autosomal recessive disorder, where both parents have an abnormal gene that is passed to the affected child.
Thus, the risk to a sibling of someone with osteopetrosis, whose parents have been examined and found not to have the disease is closer to 1:10.
  More results at FactBites »


 

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