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A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by humoral factors (by hormones or cytokines) excreted by tumor cells or by an immune response against the tumor. Sometimes the symptoms of paraneoplastic syndromes show even before the diagnosis of a malignancy. The Disease Bold textDatabase is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ...
eMedicine is an online clinical medical knowledge base that was founded in 1996. ...
The term disease refers to an abnormal condition of an organism that impairs function. ...
The term symptom (from the Greek meaning chance, mishap or casualty, itself derived from ÏÏ
μÏιÏÏÏ meaning to fall upon or to happen to) has two similar meanings in the context of physical and mental health: Strictly, a symptom is a sensation or change in health function experienced by a patient. ...
Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ...
Hormone is also the NATO reporting name for the Soviet/Russian Kamov Ka-25 military helicopter. ...
Cytokines are small protein molecules that are the core of communication between immune system cells, and even between immune system cells and cells belonging to other tissue types. ...
When normal cells are damaged or old they undergo apoptosis; cancer cells, however, avoid apoptosis. ...
Paraneoplastic syndromes can be divided into 4 main categories: mucocutane paraneoplastic syndromes, neurological paraneoplastic syndromes, haematological paraneoplastic syndromes and endocrine metabolic syndromes. Examples Examples of paraneoplastic phenomena: Lambert-Eaton myasthenic syndrome (LEMS) is a rare disorder of nerve-muscle (neuromuscular) junction. ...
Lung cancer is the malignant transformation and expansion of lung tissue, and is the most lethal of all cancers worldwide, responsible for 1. ...
Hypercalcaemia is an elevated calcium level in the blood. ...
Breast cancer is cancer of breast tissue. ...
Lung cancer is the malignant transformation and expansion of lung tissue, and is the most lethal of all cancers worldwide, responsible for 1. ...
Parathyroid hormone-related protein (or PTHrP) is a protein occasionally secreted by cancer cells (breast cancer, certain types of lung cancer). ...
Paraneoplastic cerebellar degeneration is a paraneoplastic phenomenon associated with lung, ovarian, breast, and other cancers. ...
In medicine, granulocytosis is the presence in peripheral blood of an increased number of granulocytes, a category of white blood cells. ...
Eosinophil granulocyte Basophil granulocyte Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm. ...
Insert non-formatted text hereGranulocyte-Colony Stimulating Factor (G-CSF) is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes. ...
X-Ray of the knee in a patient with dermatomyositis. ...
{{ }} Polymyositis is a type of inflammatory myopathy, related to dermatomyositis and inclusion body myositis. ...
First described by Moersch and Woltman at the Mayo Clinic in 1956, stiff person syndrome (SPS) is a rare neurologic disorder of unknown etiology. ...
Encephalomyelitis is a general term for inflammation of the brain and spinal cord, describing a number of disorders: acute disseminated encephalomyelitis or postinfectious encephalomyelitis, a demyelinating disease of the brain and spinal cord, possibly triggered by vaccination or viral infection; encephalomyelitis disseminata, a synonym for multiple sclerosis; equine encephalomyelitis, a...
Myasthenia gravis (sometimes abbreviated MG; from the Greek myastheneia, lit. ...
Neuromyotonia is spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. ...
Opsoclonus refers to a uncontrolled movement of the eyes. ...
Neuropathy, strictly speaking, is any disease that affects the nervous system. ...
The syndrome of inappropriate antidiuretic hormone (SIADH) is a condition commonly found in the hospital population, especially in patients being hospitalized for central nervous system (CNS) injury. ...
Membranous glomerulonephritis (MGN), also known as membranous nephropathy is a slowly progressive disease affecting mostly patients between ages of 30 and 50 years. ...
The sign of Leser-Trelat, the explosive onset of multiple pruritic seborrheic keratoses, often with an inflammatory base, can be an ominous sign of internal malignancy. ...
Neurological A particularly devastating form of paraneoplastic syndromes is a group of disorders classified as paraneoplastic neurological disorders (PNDs). These paraneoplastic disorders affect the brain and central nervous system and they are degenerative. Symptoms of paraneoplastic neurological disorders include ataxia (difficulty with walking and balance), dizziness, nystagmus (rapid uncontrolled eye movements), difficulty swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs. Ataxia (from Greek ataxiÄ, meaning failure to put in order) is unsteady and clumsy motion of the limbs or torso due to a failure of the gross coordination of muscle movements. ...
// Pre-syncope is a sensation of feeling faint. ...
Nystagmus is rapid involuntary rhythmic eye movement, with the eyes moving quickly in one direction (quick phase), and then slowly in the other (slow phase). ...
For other uses, see Dementia (disambiguation). ...
This article is about the medical condition. ...
The most common cancers associated with paraneoplastic neurological disorders are breast, ovarian and lung cancer, but many other cancers have been linked to PNDs as well. Breast cancer is cancer of breast tissue. ...
Ovarian cancer is a malignant ovarian neoplasm (an abnormal growth located on the ovaries). ...
Lung cancer is the malignant transformation and expansion of lung tissue, and is the most lethal of all cancers worldwide, responsible for 1. ...
Treatment options include: - Therapies to eliminate the underlying cancer such as chemotherapy, radiation and surgery, and
- Therapies to reduce or slow neurological degeneration. Rapid diagnosis and treatment is critical for the patient to have the best chance of recovery. Since these disorders are relatively rare, few doctors have seen or treated PNDs. Therefore, it is important that PND patients consult with a specialist with experience in diagnosing and treating paraneoplastic neurological disorders.
Organisations The International Paraneoplastic Association (IPA) is an organization dedicated to providing support and information to those affected by paraneoplastic neurological disorders.
External links - http://www.antibodypatterns.com/hu.php
Benign - Premalignant - Carcinoma in situ - Malignant Pathology (from Greek pathos, feeling, pain, suffering; and logos, study of; see also -ology) is the study of the processes underlying disease and other forms of illness, harmful abnormality, or dysfunction. ...
Tumor or tumour literally means swelling, and is sometimes still used with that meaning. ...
Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ...
Oncology is the medical subspecialty dealing with the study and treatment of cancer. ...
Benign can refer to any medical condition which, untreated or with symptomatic therapy, will not become life-threatening. ...
A premalignant condition is a disease, syndrome, or finding that, if left untreated, may lead to cancer. ...
Carcinoma in situ is present when a tumor has been detected that has the characteristics of malignancy but has not invaded other tissues. ...
In medicine, malignant is a clinical term that means to be severe and become progressively worse, as in malignant hypertension. ...
Topography: Anus - Bladder - Bile duct - Bone - Brain - Breast - Cervix - Colon/rectum - Duodenum - Endometrium - Esophagus - Eye - Gallbladder - Head/Neck - Liver - Larynx - Lung - Mouth - Pancreas - Penis - Prostate - Kidney - Ovaries - Skin - Stomach - Testicles - Thyroid Anal cancer is a distinct entity from the more common colorectal cancer. ...
Bladder cancer refers to any of several types of malignant growths of the urinary bladder. ...
// [edit] Introduction Cholangiocarcinoma is an adenocarcinoma of the biliary duct system. ...
An arm bone tumor Bone tumor is an inexact term, which can be used for both benign and malignant abnormal growths found in bone, but is most commonly used for primary tumors of bone, such as osteosarcoma (or osteoma). ...
A brain tumor is any intracranial tumor created by abnormal and uncontrolled cell division, normally either found in the brain itself (neurons, glial cells (astrocytes, oligodendrocytes, ependymal cells), lymphatic tissue, blood vessels), in the cranial nerves (myelin-producing Schwann cells), in the brain envelopes (meninges), skull, pituitary and pineal gland...
Breast cancer is cancer of breast tissue. ...
Cervical cancer is a malignancy of the cervix. ...
Colorectal cancer, also called colon cancer or bowel cancer, includes cancerous growths in the colon, rectum and appendix. ...
This article needs more context around or a better explanation of technical details to make it more accessible to general readers and technical readers outside the specialty, without removing technical details. ...
Endometrial cancer involves cancerous growth of the endometrium (lining of the uterus). ...
Esophageal cancer is malignancy of the esophagus. ...
Ocular oncology is branch of medicine dealing with tumors relating to the eye and its adnexa. ...
Bold textA more uncommon cancer predominate in females, if found early on before symptoms, can be cured by removing Gallbladder, most often it is found after symptoms occur (abdominal pain, Jaundice) and has spread to other organs such as liver and the outlook at this point is poor. ...
Head and neck cancers are malignant growths originating in the lip and oral cavity (mouth), nasal cavity, pharynx, larynx, thyroid, paranasal sinuses, salivary glands and cervical lymph nodes of the neck. ...
Hepatocellular carcinoma (HCC, also called hepatoma) is a primary malignancy (cancer) of the liver. ...
Cancer of the larynx also may be called laryngeal cancer. ...
Lung cancer is the malignant transformation and expansion of lung tissue, and is the most lethal of all cancers worldwide, responsible for 1. ...
Oral cancer is any cancerous tissue growth located in the mouth. ...
Pancreatic cancer (also called cancer of the pancreas) is a malignant tumour within the pancreatic gland. ...
Penile cancer is a malignant growth found on the skin or in the tissues of the penis, usually originating in the glans and/or foreskin. ...
Prostate cancer is a disease in which cancer develops in the prostate, a gland in the male reproductive system. ...
Renal cell carcinoma, also known by a gurnistical tumor, is the most common form of kidney cancer arising from the renal tubule. ...
Ovarian cancer is a malignant ovarian neoplasm (an abnormal growth located on the ovaries). ...
Skin cancer is a malignant growth on the skin, which can have many causes. ...
Stomach cancer (also called gastric cancer) can develop in any part of the stomach and may spread throughout the stomach and to other organs; particularly the esophagus and the small intestine. ...
Testicular cancer is a type of cancer that develops in the testicles, a part of the male reproductive system. ...
Morphology: Papilloma/carcinoma - Choriocarcinoma - Adenoma/adenocarcinoma - Soft tissue sarcoma - Melanoma - Fibroma/fibrosarcoma - Metastasis - Lipoma/liposarcoma - Leiomyoma/leiomyosarcoma - Rhabdomyoma/rhabdomyosarcoma - Mesothelioma - Angioma/angiosarcoma - Osteoma/osteosarcoma - Chondroma/chondrosarcoma - Glioma - Lymphoma/leukemia Papilloma refers to a benign epithelial tumor. ...
In medicine, carcinoma apanting dog named rufis It is malignant by definition: carcinomas invade surrounding tissues and organs, and may spread to lymph nodes and distal sites (metastasis). ...
Choriocarcinoma is a rare cancer of the placenta, curable by chemotherapy. ...
Adenoma refers to a collection of growths (-oma) of glandular origin. ...
Adenocarcinoma is a form of carcinoma that originates in glandular tissue. ...
Malignant (cancerous) tumors that develop in soft tissue are called sarcomas, a term that comes from a Greek word meaning fleshy growth. ...
Melanoma is a malignant tumor of melanocytes. ...
Soft Fibroma (fibroma molle). ...
Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells. ...
Metastasis (Greek: change of the state) is the spread of cancer from its primary site to other places in the body. ...
A lipoma is a common, benign tumor composed of fatty tissue. ...
Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum. ...
A leiomyoma (plural is leiomyomata) is a benign smooth muscle neoplasm that is not premalignant. ...
Leiomyosarcoma is a type of sarcoma which is a neoplasm of smooth muscle. ...
A rhabdomyoma is a benign tumor of muscle. ...
A rhabdomyosarcoma is a type of cancer, specifically a sarcoma (cancer of connective tissues), in which the cancer cells are thought to arise from skeletal muscle progenitors. ...
Angiomas are benign tumors that are made up of small blood vessels. ...
Angiosarcoma is a rare, malignant tumor consisting of endothelial and fibroblastic tissue that proliferates and eventually surrounds vascular channels. ...
An osteoma is a new piece of bone growing on another piece, typically the skull. ...
Osteosarcoma is a common primary bone cancer. ...
A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. ...
A chondrosarcoma is a cancer of the cartilage. ...
A glioma is a type of primary central nervous system (CNS) tumor that arises from glial cells. ...
This article is about lymphoma in humans. ...
Leukemia or leukaemia (see spelling differences) is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation (production by multiplication) of blood cells, usually white blood cells (leukocytes). ...
Treatment: Surgery - Chemotherapy - Radiation therapy - Immunotherapy - Experimental cancer treatment A cardiothoracic surgeon performs a mitral valve replacement at the Fitzsimons Army Medical Center. ...
Chemotherapy is the use of chemical substances to treat disease. ...
Clinac 2100 C100 accelerator Radiation therapy (or radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ...
Cancer Immunotherapy is the use of monoclonal antibodies (-mab) to specifically target cells. ...
Experimental cancer treatments are medical therapies intended or claimed to treat cancer (see also tumor) by improving on, supplementing or replacing conventional methods (surgery, chemotherapy, radiation, and immunotherapy). ...
Related structures: Cyst - Dysplasia - Hamartoma - Neoplasia - Nodule - Polyp - Pseudocyst A cyst is a closed sac having a distinct membrane and developing abnormally in a cavity or structure of the body. ...
Dysplasia (latin for bad form) is an abnormality in the appearance of cells indicative of an early step towards transformation into a neoplasia. ...
A hamartoma is a common benign tumor in an organ composed of tissue elements normally found at that site but that are growing in a disorganized mass. ...
Neoplasia (new growth in Greek) is abnormal, disorganized growth in a tissue or organ, usually forming a distinct mass. ...
In medicine, a nodule refers to a small aggregation of cells. ...
Polyp of sigmoid colon as revealed by colonoscopy. ...
A pseudocyst is a pathological collection of fluid. ...
Misc: Tumor suppressor genes/oncogenes - Staging/grading - Carcinogenesis/metastasis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-related terms A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. ...
An oncogene is a modified gene that increases the malignancy of a tumor cell. ...
The stage of a cancer is a descriptor (usually numbers I to IV) of how much the cancer has spread. ...
In pathology, Grading is a measure of the progress of tumors. ...
Cancers are caused by a series of mutations. ...
Metastasis (Greek: change of the state) is the spread of cancer from its primary site to other places in the body. ...
The term carcinogen refers to any substance, radionuclide or radiation which is an agent directly involved in the promotion of cancer or in the facilitation of its propagation. ...
Cancer research is research into cancer in order to identify causes and develop strategies for prevention, diagnosis, treatments and cure. ...
The International Classification of Diseases for Oncology (ICD-O) is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. ...
This is a list of terms related to oncology. ...
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