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Parkinsonism (also known as Parkinson's syndrome, atypical Parkinson's, or secondary Parkinson's) is a neurological syndrome characterized by tremor, hypokinesia, rigidity, and postural instability.[1] The underlying causes of parkinsonism are numerous, and diagnosis can be complex.[2] While the neurodegenerative condition Parkinson's disease (PD) is the most common cause of parkinsonism, a wide-range of other etiologies can lead to a similar set of symptoms, including some toxins, a few metabolic diseases, and a handful of non-PD neurological conditions.[3] The Disease Bold textDatabase is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ...
MedlinePlus (medlineplus. ...
In medicine, the term syndrome is the association of several clinically recognizable features, signs, symptoms, phenomena or characteristics which often occur together, so that the presence of one feature alerts the physician to the presence of the others. ...
For the film see Tremors (film). ...
Slow or diminished movement of body musculature. ...
Spasticity is a disorder of the bodys motor system in which certain muscles are continuously contracted. ...
Balance is the result of a number of body systems working together. ...
Neurodegenerative disease is a condition which affects brain function. ...
Etiology (alternately aetiology, aitiology) is the study of causation. ...
For a list of biologically injurious substances, including toxins and other materials, as well as their effects, see poison. ...
A metabolic disease is a disease caused by malfunction in the human total metabolism. ...
Etiology
If PD has been excluded, the differential diagnosis or list of potential causes for this syndrome includes: This article does not cite any references or sources. ...
- AIDS can sometimes lead to the symptoms of Parkinson's disease, due to commonly causing dopaminergic dysfunction.[4]
- Corticobasal degeneration[1]
- Creutzfeldt-Jakob disease[5]
- Diffuse Lewy body disease[1]
- Drug-induced parkinsonism (due to drugs such as antipsychotics, metoclopramide, MPTP[6])[1]
- Encephalitis lethargica[1]
- Multiple system atrophy[7]
- Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome)[8]
- Progressive supranuclear palsy[1]
- Toxicity due to substances such as carbon monoxide,[9] carbon disulfide,[9] manganese,[9] paraquat,[10] hexane, rotenone, and toluene. [citation needed]
- Vascular Parkinsonism[11]
- Wilson's disease is a genetic disorder in which there is an abnormal accumulation of copper. The excess copper can lead to the formation of a copper-dopamine complex, which leads to the oxidation of dopamine to aminochrome.[12]
- Paraneoplastic Syndrome (PNS). A neurological disease related to incipient cancer which manifests itself with neurological symptoms similar to actual neurological diseases or disorders.
Acquired Immune Deficiency Syndrome or acquired immunodeficiency syndrome (AIDS or Aids) is a collection of symptoms and infections resulting from the specific damage to the immune system caused by the human immunodeficiency virus (HIV). ...
Corticobasal degeneration (CBD) is a progressive neurodegenerative disease associated with atrophy of the cerebral cortex and the basal ganglia. ...
Creutzfeldt-Jakob disease (CJD) is a very rare and incurable degenerative neurological disorder (brain disease) that is ultimately fatal. ...
Dementia with Lewy bodies is the second most frequent cause of hospitalization for dementia, after Alzheimers disease. ...
The term antipsychotic is applied to a group of drugs used to treat psychosis. ...
Metoclopramide (INN) (IPA: ) is a potent dopamine receptor antagonist used for its antiemetic and prokinetic properties. ...
This article is about the chemical. ...
Encephalitis lethargica is an atypical form of encephalitis. ...
Multiple system atrophy (MSA) is a degenerative neurological disorder. ...
PKAN: Pantothenate Kinase-Associated Neurodegeneration Symptoms Pantothenate kinase-associated neurodegeneration (PKAN) is one of many forms of neurodegeneration, or brain deterioration . ...
Progressive supranuclear palsy (PSP) (or the Steele-Richardson-Olszewski syndrome, after the Canadian physicians who described it in 1963 ) is a rare degenerative disorder involving the gradual deterioration and death of selected areas of the brain. ...
Carbon monoxide, with the chemical formula CO, is a colorless, odorless, and tasteless gas. ...
Carbon disulfide is a colorless liquid with the formula CS2. ...
Manganism or manganese poisoning is a toxic condition resulting from chronic exposure to manganese and first identified in 1837 by J. Couper. ...
Paraquat is the trade name for N,N-Dimethyl-4,4-bipyridinium dichloride, a viologen. ...
the 3rd ingredient in big mac ...
Rotenone is a colorless-to-red, odorless solid. ...
Toluene, also known as methylbenzene or phenylmethane is a clear, water-insoluble liquid with the typical smell of paint thinners, redolent of the sweet smell of the related compound benzene. ...
Wilsons disease or hepatolenticular degeneration is an autosomal recessive hereditary disease, with an incidence of about 1 in 30,000 in most parts of the world and a male preponderance. ...
References - ^ a b c d e f Aminoff MJ, Greenberg DA, Simon RP (2005). Clinical Neurology, 6th ed., Lange: McGraw-Hill Medical, 241–5. ISBN 0071423605.
- ^ Tuite PJ, Krawczewski K (2007). "Parkinsonism: a review-of-systems approach to diagnosis". Seminars in neurology 27 (2): 113-22. DOI:10.1055/s-2007-971174. PMID 17390256.
- ^ Christine CW, Aminoff MJ (2004). "Clinical differentiation of parkinsonian syndromes: prognostic and therapeutic relevance". Am. J. Med. 117 (6): 412-9. DOI:10.1016/j.amjmed.2004.03.032. PMID 15380498.
- ^ Tse W, Cersosimo MG, Gracies JM, et al (2004). "Movement disorders and AIDS: a review". Parkinsonism Relat. Disord. 10 (6): 323-34. DOI:10.1016/j.parkreldis.2004.03.001. PMID 15261874.
- ^ Maltête D, Guyant-Maréchal L, Mihout B, Hannequin D (2006). "Movement disorders and Creutzfeldt-Jakob disease: a review". Parkinsonism Relat. Disord. 12 (2): 65-71. DOI:10.1016/j.parkreldis.2005.10.004. PMID 16364674.
- ^ Watanabe Y, Himeda T, Araki T (2005). "Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease" (PDF). Med. Sci. Monit. 11 (1): RA17-23. PMID 15614202.
- ^ Wenning GK, Geser F (2003). "Multiple system atrophy". Rev. Neurol. (Paris) 159 (5 Pt 2): 3S31-8. PMID 12773886.
- ^ Uc EY, Rodnitzky RL (2003). "Childhood dystonia". Seminars in pediatric neurology 10 (1): 52-61. PMID 12785748.
- ^ a b c DeLong MR, Juncos JL (2004). Parkinson's Disease and Other Movement Disorders. In: Harrison's Principles of Internal Medicine, 16th ed., McGraw-Hill Professional, p. 2414. ISBN 0-07-140235-7.
- ^ Dinis-Oliveira RJ, Remião F, Carmo H, et al (2006). "Paraquat exposure as an etiological factor of Parkinson's disease". Neurotoxicology 27 (6): 1110-22. DOI:10.1016/j.neuro.2006.05.012. PMID 16815551.
- ^ Thanvi B, Lo N, Robinson T (2005). "Vascular Parkinsonism--an important cause of parkinsonism in older people" (PDF). Age and ageing 34 (2): 114-9. DOI:10.1093/ageing/afi025. PMID 15713855.
- ^ Członkowska A, Tarnacka B, Möller JC, et al (2007). "Unified Wilson's Disease Rating Scale - a proposal for the neurological scoring of Wilson's disease patients". Neurol. Neurochir. Pol. 41 (1): 1-12. PMID 17330175.
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