Although a frequent disease, the specific inflammatory patterns or regulation of immune response and the pathogenesis of cytopathic effects in human influenza is incompletely understood.
The pathogenesis is characterized by the rapid replication and distribution of the virus within the lungs, causing local and systemic inflammation and cytokine release.
Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses.