Percodan® is a potent opioid painkiller used to treat moderately severe to severe acute (short-term) pain. Percodan was first marketed by DuPont Pharmaceuticals and prescribed in the United States in 1950. At one time one of the most widely prescribed painkillers, Percodan has largely been replaced by safer alternatives. An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. ... For other uses of painkiller, see painkiller (disambiguation) An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain. ... Acute may refer to: An acute accent is a diacritic character. ... Look up Pain in Wiktionary, the free dictionary. ... Traditionally, Marketing has been a term applied to the craft of linking the producers (or potential producers) of a product or service with customers, both existing and potential. ... This article is about the DuPont company. ... 1950 (MCML) was a common year starting on Sunday (link will take you to calendar). ...

Pharmacology

Each Percodan tablet contains the following active ingredients: 4.5 mg of oxycodone hydrochloride, 0.38 mg of oxycodone terephthalate, and 325 mg of aspirin. Each tablet also contains the following inactive ingredients: FD&C Yellow 10, FD&C Yellow 6, microcrystalline cellulose and starch. The oxycodone component in Percodan is technically 14-hydroxydihydrocodeinone, a white odorless, crystalline powder which is synthesized from the opium alkaloid thebaine. Thebaine by itself has no therapeutic value. Oxycodone is metabolized into oxymorphone. Unlike morphine and like codeine, oxycodone has a good oral potency. Prior to the introduction of acetaminophen (Tylenol), Percodan was the mainstay in post-operative oral pain treatment due to the potency and long half-life of oxycodone. Percodan originally contained a small amount of caffeine. Common disk-shaped tablets A pharmacological tablet is a medicinal or other active substance mixed with binder powders and pressed into a tablet form. ... An active ingredient, also active pharmaceutical ingredient (or API), is the substance in drug that is pharmaceutically active. ... The milligram (symbol mg) is an SI unit of mass. ... Oxycodone is a very powerful and potentially addicting opioid analgesic medication synthesized from thebaine. ... Oxycodone is a very powerful and potentially addicting opioid analgesic medication synthesized from thebaine. ... Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ... Sunset Yellow FCF (also known as Orange Yellow S, and FD&C Yellow 6) is a colourant that may be added to foods to induce a colour change. ... Microcrystalline Cellulose is an excipient used in the formulation of tablets and capsules. ... Starch is a complex carbohydrate which is insoluble in water, it is used by plants as a way to store excess glucose. ... Oxycodone is a very powerful and potentially addicting opioid analgesic medication synthesized from thebaine. ... White is a color, (more accurately it contains all the colors of the visible spectrum and is sometimes described as an achromatic color—black is the absence of color) that has high brightness but zero hue. ... ... Crystal (disambiguation) Insulin crystals A crystal is a solid in which the constituent atoms, molecules, or ions are packed in a regularly ordered, repeating pattern extending in all three spatial dimensions. ... Powder is a substance that has been crushed into very fine grains. ... Synthesis (from the Greek words syn = plus and thesis = position) is commonly understood to be an integration of two or more pre-existing elements which results in a new creation. ... Opium is a narcotic analgesic drug which is obtained from the unripe seed pods of the opium poppy (Papaver somniferum L. or the synonym paeoniflorum). ... An alkaloid is a nitrogenous organic molecule that has a pharmacological effect on humans and animals. ... A minor constituent of opium, thebaine or paramorphine (C19H21NO3) is chemically similar to both morphine and codeine, but produces stimulatory rather than depressant effects. ... Therapy (in Greek: θεραπεία) or treatment is the attempted remediation of a health problem, usually following a diagnosis. ... Value is worth in general, and it is thought to be connected to reasons for certain practices, policies, actions, beliefs or emotions. ... Oxymorphone (Numorphan) is a powerful semi-synthetic narcotic analgesic that is derived from morphine, and is approximately 6-8 times more potent. ... Morphine (INN), the principal active agent in opium, is a powerful opioid analgesic drug. ... Codeine (INN) or methylmorphine is an opioid used for its analgesic, antitussive and antidiarrheal properties. ... Erectile dysfunction, also known as impotence, is the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. ... Acetaminophen (USAN) or paracetamol (INN), is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. ... Tylenol (paracetamol, also known as acetaminophen) is a popular American brand of pain reliever and fever reducer, sold by Johnson & Johnson. ... Half-Life For a quantity subject to exponential decay, the half-life is the time required for the quantity to fall to half of its initial value. ... Caffeine (sometimes called guaranine when found in guarana, mateine when found in mate, and theine when found in tea) is a xanthine alkaloid found in the leaves and beans of the coffee tree, in tea, yerba mate, guarana berries, and in small quantities in cocoa, the kola nut and the...

Decline of Use

Percodan has largely been replaced by Percocet (which is a compound of oxycodone and acetaminophen, instead of Percodan's aspirin) and other oxycodone-containing compounds for post-operative pain, since aspirin and other anti-inflammatory drugs increase prothrombin time and thus inhibit the blood from clotting, which can result in post-operative complications, such as excessive bleeding. In the United States, Percodan is regulated as a Schedule II controlled substance under the Uniform Controlled Substances Act of 1970, along with cocaine, morphine and raw opium. Schedule II prescriptions may not be filled telephonically (except in an emergency), and no refills are allowed. Percodan is becoming something of a relic in the United States, at least, as the number of prescriptions has fallen precipitously since the 1960s in light of the safer and stronger drugs available containing oxycodone (Percocet, Tylox, OxyContin, Roxicodone, Percocet 10/325). Oxycodone is a very powerful and potentially addictive opioid analgesic medication synthesized from thebaine. ... A chemical compound is a chemical substance formed from two or more elements, with a fixed ratio determining the composition. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Thrombin (activated Factor II) is a coagulation protein that has many effects in the coagulation cascade. ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ... Wikipedia does not yet have an article with this exact name. ... The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 (21 USC 13). ... This article is about the drug cocaine. ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ... Oxycodone is a very powerful and potentially addicting opioid analgesic medication synthesized from thebaine. ... Oxycodone is a very powerful and potentially addicting opioid analgesic medication synthesized from thebaine. ...

Miscellaneous

Percodan is also sold under the brand name Endodan®. All products containing oxycodone (including Percodan, Percocet, OxyContin) have the potential to be habit-forming. Oxycodone can produce drug dependence of the morphine type and, therefore, has the potential for being abused. Percodan is subject to the Federal Controlled Substances Act (Schedule II); it is a favorite of and eagerly sought after by opiate addicts; most opiate addicts, however, prefer OxyContin because it does not contain any other active ingredients besides oxycodone, unlike Percodan and Percocet, which each contain aspirin and Tylenol, respectively. Drug abuse has a wide range of definitions, all of them relating to the use, misuse or overuse of a psychoactive drug or performance enhancing drug for a non-therapeutic or non-medical effect. ... Dependency has a number of meanings: In project management, a dependency is a link amongst a projects terminal elements. ... Abuse is a general term for the misuse of a person or thing, causing harm to the person or thing, to the abuser, or to someone else. ... The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 (21 USC 13). ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ...

Percodan and Percocet are currently (2006) manufactured by Endo Pharmaceuticals. 2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ...

Dosage

The usual adult dosage of Percodan is one tablet by mouth every 6 hours as needed for pain, not to exceed 12 tablets in 24 hours in any event. Dosage is Collective Souls fourth studio album, released on February 9, 1999. ...

External links

• Percodan Prescribing Information from Endo Pharmaceuticals.
• Endo Pharmaceuticals.