Glutathione Peroxidase 1

A peroxidase (eg. EC 1.11.1.9) is an enzyme, which may contain heme, that catalyzes a reaction of the form: Gen w/ Deepview from PDB:1GP1 File links The following pages link to this file: Peroxidase Glutathione peroxidase Categories: Free use images | Protein images ... Gen w/ Deepview from PDB:1GP1 File links The following pages link to this file: Peroxidase Glutathione peroxidase Categories: Free use images | Protein images ... EC numbers (Enzyme Commission numbers) are a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... Ribbon diagram of the catalytically perfect enzyme TIM. Factor D enzyme crystal prevents the immune system from inappropriately running out of control. ... A hæm or heme is a metal-containing cofactor that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. ...

ROOR' + electron donor (2 e^-) + 2H⁺ → ROH + R'OH

For many of these enzymes the optimal substrate is hydrogen peroxide, but others are more active with organic hydroperoxides such as lipid peroxides. Hydrogen peroxide (H2O2) is a clear liquid, slightly more viscous than water, that has strong oxidizing properties and is therefore a powerful bleaching agent that has found use as a disinfectant and (in high concentrations as high test peroxide) as an oxidizer or monopropellant in rockets. ...

The nature of the electron donor is very dependent on the structure of the enzyme. For example, horseradish peroxidase can use a variety of organic compounds as electron donors and acceptors. Horseradish peroxidase has a broad and accessible active site and many compounds can reach the site of the reaction. For an enzyme such as cytochrome c peroxidase, the compounds that donate electrons are very specific, because there is a very closed active site. In chemistry, a nucleophile (literally nucleus lover) is a reagent which is attracted to centres of positive charge. ... Binomial name Armoracia rusticana P.G. Gaertn. ... The active site of an enzyme is the binding site where catalysis occurs. ... Cytochrome c peroxidase, or CCP,( PDB 2CYP, EC 1. ...

Peroxidases are sometimes used as histological markers. Cytochrome c peroxidase is used as a soluble, easily purified model for cytochrome c oxidase. Histology is the study of tissue sectioned as a thin slice, using a microscope. ... Cytochrome c peroxidase, or CCP,( PDB 2CYP, EC 1. ... Cytochrome c oxidase The enzyme cytochrome c oxidase (PDB 2OCC, EC 1. ...

Glutathione peroxidase is a peroxidase found in humans, which contains selenocysteine. It uses glutathione as a electron donor and is active with both hydrogen peroxide and organic hydroperoxide substrates. Categories: Biochemistry stubs | EC 1. ... Selenocysteine is an amino acid that is present in several enzymes (for example glutathione peroxidases, tetraiodothyronine 5 deiodinases, thioredoxin reductases, formate dehydrogenases, glycine reductases and some hydrogenases). ... Glutathione (GSH), whose IUPAC name is 2-amino-5-{[2-[(carboxymethyl)amino]-1-(mercaptomethyl)-2-oxoethyl]amino}-5-oxopentanoic acid, is gamma-glutamylcysteinylglycine, a tripeptide. ... Hydrogen peroxide (H2O2) is a clear liquid, slightly more viscous than water, that has strong oxidizing properties and is therefore a powerful bleaching agent that has found use as a disinfectant and (in high concentrations as high test peroxide) as an oxidizer or monopropellant in rockets. ...

See also

• myeloperoxidase (MPO)
• catalase
• hemoprotein
• peroxide