Philip Montagu D’Arcy Hart, CBE, (June 25, 1900 - July 30, 2006) was a British medical researcher and pioneer in tuberculosis treatment. Grandson of Samuel Montagu, 1st Baron Swaythling. CBE can stand for: Commander of the Order of the British Empire, a grade in the Order of the British Empire Calgary Board of Education, public school board for the city of Calgary, Alberta CBE (AM), callsign of the CBC Radio One AM station in Windsor, Ontario CBE-FM, callsign... June 25 is the 176th day of the year (177th in leap years) in the Gregorian Calendar, with 189 days remaining. ... 1900 (MCM) was an exceptional common year starting on Monday of the Gregorian calendar, but a leap year starting on Saturday of the Julian calendar. ... July 30 is the 211th day (212th in leap years) of the year in the Gregorian Calendar, with 154 days remaining. ... 2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ... Tuberculosis (abbreviated as TB for Tubercle Bacillus) is a common and deadly infectious disease caused by the bacterium Mycobacterium tuberculosis, which most commonly affects the lungs (pulmonary TB) but can also affect the central nervous system, lymphatic system, circulatory system, genitourinary system, bones and joints. ... Samuel Montagu, 1st Baron Swaythling (1832 - 1911) was an English Jewish banker, who founded the bank of Samuel Montagu & Co in 1853. ...

Hart was educated at Clifton College, near Bristol, and Gonville and Caius College, Cambridge, where he read medicine. He moved to University College Hospital medical school, London, for his training in clinical medicine, qualifying as a physician in 1925. He obtained an MD by thesis in 1930. At that time UCH boasted an unusual number of distinguished clinician-scientists. Hart thrived in the academic atmosphere and became a consultant in 1934. Such posts at London teaching hospitals were unpaid; the holder was expected to set up a private medical practice to make a living. Hart did not find this arrangement congenial, being left no time for research. So he abandoned a secure career in clinical medicine in 1937 to join the Medical Research Council for a working life of medical research and its administration. An 1898 etching of the College Close Clifton College is a major coeducational public school in Clifton, Bristol, England. ... Full name Gonville and Caius College Motto - Named after Edmund Gonville & John Caius Previous names Gonville Hall (1348), Gonville & Caius (1557) Established 1348 Sister College Brasenose College Master Neil McKendrick Location Trinity St Undergraduates 468 Graduates 291 Homepage Boatclub Gonville and Caius College, Cambridge, generally known as Caius (though pronounced... Shown within Cambridgeshire Geography Status City (1951) Region East of England Admin. ... Categories: Stub | London hospitals ... Current MRC logo The Medical Research Council (MRC) is a UK organisation dedicated to promot[ing] the balanced development of medical and related biological research in the UK. Organisation The MRC is one of seven Research Councils and is answerable to, although politically independent from, the Office of Science and...

His particular interest was in tuberculosis, which in the first part of the 20th century was as grave a problem in western countries as it remains today in the developing world. He had spent a year working with René Dubos at the Rockefeller Institute in New York immediately after becoming a consultant. However, his first work for the MRC was in south Wales, investigating pneumoconiosis, a disabling and potentially fatal disease of coal miners. It was not at the time clear whether this was a condition distinct from silicosis or that coal dust (as distinct from silica dust caused by rock mining) could cause any pathology. The issue had financial implications, because if coal dust was harmful, those affected were entitled to industrial injury benefit from the state. Hart's group was able to show that the prevalence of the condition increased as one moved further west in the south Wales coalfield, and that this correlated with the hardness of the coal and hence with the amount of dust generated in extracting it. Tuberculosis (abbreviated as TB for Tubercle Bacillus) is a common and deadly infectious disease caused by the bacterium Mycobacterium tuberculosis, which most commonly affects the lungs (pulmonary TB) but can also affect the central nervous system, lymphatic system, circulatory system, genitourinary system, bones and joints. ... René Jules Dubos (1901-1982), was a French-born American microbiologist, experimental pathologist, environmentalist, humanist, and Pulitzer Prize-winning author who exemplified qualities of the modern Renaissance person. ... Rockefeller University is a small private university focusing primarily on graduate education and research in the biomedical fields, located in the southeasternmost corner of the Upper East Side of Manhattan island in New York City, New York. ... Pneumoconiosis, also known as miners lung, is a lung condition caused by the inhalation of dust, characterized by formation of nodular fibrotic changes in lungs. ... Silicosis (also known as Grinders disease) is a form of pneumoconiosis caused by inhalation of crystalline silica dust, and is marked by inflammation and scarring in forms of nodular lesions in the upper lobes of the lungs. ...

The pneumoconiosis unit closed early in the second world war and Hart was transferred to the tuberculosis research unit in London, becoming its head from 1948 until he retired in 1965. The unit had many achievements, at first relating primarily to the control of the disease in the UK but later in many parts of the world. Perhaps the work of which Hart was most proud was the demonstration by controlled clinical trials, at a time when such trials were novel and their necessity much debated, of the efficacy of streptomycin in treating tuberculosis - the first effective non-surgical treatment for this disease. In medicine, a clinical trial (synonyms: clinical studies, research protocols, medical research) is a research study. ... Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. ...

Better known is the massive trial of bacille Calmette-Guérin or BCG as a vaccine in thousands of schoolchildren, which demonstrated induction of strong and persistent protection and has been the basis of public health policy. (Universal BCG vaccination delivered through schools has been replaced with targeted vaccination for individuals at greatest risk.) Unfortunately the efficacy of BCG varies widely among countries, and the UK finding cannot everywhere be successfully applied. Image:A scar after received Bacillus Calmette-Guérin. ... BCG can stand for: Bacillus Calmette-Guérin (a vaccine for tuberculosis) Boston Consulting Group This is a disambiguation page — a navigational aid which lists other pages that might otherwise share the same title. ...

The tuberculosis research unit was based at the old National Institute for Medical Research in Hampstead, north London, where there were no facilities for laboratory work on tuberculosis. Hart set up such facilities at the future site of the institute in Mill Hill. When the new institute opened, it included state-of-the-art facilities for safe handling of mice infected with tuberculosis. The National Institute For Medical Research, commonly abbreviated to NIMR, is a fairly large medical institute situated in rural Mill Hill, England. ...

When he retired in 1965 he moved full time to Mill Hill with a research grant from the MRC. At the same time he shed his advisory and administrative commitments so that he could concentrate on laboratory work, taking up ideas he had had no time to explore while head of an MRC unit.

So began a period of impressively productive research, which continued until Hart had passed his 100th birthday. His aim had been to study a group of surface-active substances which had the property of affecting the growth of the tubercle bacillus only when it was growing in living cells. Though Hart was able to obtain further information about these compounds, he was unable to determine how they worked. Largely as a result of his persistence, the investigation has recently been restarted.

Meanwhile Hart had discovered a fundamental property of the Mycobacterium tuberculosis growing within cells: its ability to interfere with the normal mechanisms by which phagocytic cells destroy ingested micro-organisms. At a morphological level this was manifested as a failure of phagosomes containing live (but not dead) bacilli to fuse with potentially bacteriolytic lysosomes. Binomial name Mycobacterium tuberculosis Zopf 1883 Mycobacterium tuberculosis is the bacterium that causes most cases of tuberculosis[1]. It was first described on March 24, 1882 by Robert Koch, who subsequently received the Nobel Prize in physiology or medicine for this discovery in 1905. ...

In collaboration with the electron microscopist John Armstrong, Hart developed electron and light microscopical methods to quantify this failure to fuse, and investigated the ability of various mycobacterial and other substances to affect it. The particular natural product or process of the Mycobacterium tuberculosis that accomplishes this interference with the host cell remains unknown but is still being investigated. It is clearly of fundamental importance in understanding how the Mycobacterium tuberculosis survives in its host to cause tuberculosis.

Though his mind remained characteristically acute, Hart suffered in his later years with increasing deafness and poor vision, as well as with neurological problems affecting his mobility. It was this physical deterioration that forced him to abandon work in the laboratory and retire - for a second time - in 2002.

Hart enjoyed books and films and plays; his comments and criticisms were always enlightening. Physical disabilities eventually limited his enjoyment of foreign travel, except for visits to his son and his family in the United States. Mobility problems also curtailed his fly-fishing, a difficult art at which he had been successful.

An important aspect of Hart was his socialism. He was active in the Socialist Medical Association, which in the 1930s supported the setting up of a system very similar to the National Health Service as established in 1947. Tuberculosis was a problem, especially in industrial towns, and of great interest to the society. There was no effective treatment and it was this, as well as general dissatisfaction with a system in which access to treatment was so inequitably distributed among the population, which led Hart to leave clinical medicine in favour of research. Socialism refers to a broad array of doctrines or political movements that envisage a socio-economic system in which property and the distribution of wealth are subject to social control. ... {{redirect|NHS} The logo of the NHS for England. ...

He is survived by his wife, Ruth, and their son, Oliver.

External Links

http://www.jameslindlibrary.org/trial_records/20th_Century/1940s/MRC_bmj/hart_biog.html

http://bmj.bmjjournals.com/collections/century/data/darcy.htm

http://www.jem.org/cgi/content/full/203/9/2047

Obituaries

http://www.iuatld.org/upload/home_news/hart_uk_199.pdf

http://www.guardian.co.uk/obituaries/story/0,,1860651,00.html

http://news.independent.co.uk/people/obituaries/article1221277.ece

http://www.ilep.org.uk/?niid=222&id=13