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Encyclopedia > Phillip A. Sharp

Philip Allen Sharp (born 1944), U.S. geneticist and molecular biologist; co-discovered gene splicing; shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence".


Sharp was born in Falmouth, Kentucky. After his Ph.D. in chemistry at the University of Illinois in 1969, he worked at the California Institute of Technology until 1971, where he studied plasmids and, later, gene expression in human cells at the Cold Spring Harbor Laboratory under James Dewey Watson.


In 1974, he received a call from Salvador Luria to the MIT.


Sharp had married Ann Holcombe in 1964. They have three daughters.


External links

  • Autobiography (http://nobelprize.org/medicine/laureates/1993/sharp-autobio.html) at the Nobel site
  • Sharp's Research at MIT (http://web.mit.edu/biology/www/facultyareas/facresearch/sharp.shtml)
  • The Phil Sharp Lab (http://web.mit.edu/sharplab/)


 

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