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BioMed Central | Full text | Plasma proteins in a standardised skin mini-erosion (II): effects of extraction pressure (1440 words) |
 | The study was undertaken using the same subjects, materials and methods as described in: "Plasma proteins in a standardised skin mini-erosion (I): permeability changes as a function of time" [4]. |
| The time course for the concentrations of the individual proteins was roughly similar in both extraction-pressure groups, indicating that the initial inflammatory stimulus was the determining factor. |
| Samples extracted with higher negative pressure contained a lower protein concentration at 0 h, indicating an increased water fraction and that the sieve function of the vascular wall was intact. |
| BioMed Central | Full text | Plasma proteins in a standardised skin mini-erosion (I): permeability changes as a ... (3630 words) |
| For the individual proteins, the relative mean concentrations were 65 ± 36% for insulin, 48 ± 12% for albumin, 30 ± 19% for transferrin, 31 ± 15%for IgG and 19.5 ± 10% for alpha-2-macroglobulin. |
| Transport of plasma proteins over the endothelium from the vascular space to the interstitium is considered to be a passive process governed by the laws of convection and diffusion. |
| For the remaining proteins, the IF/plasma ratios at 0 h are similar for albumin and alpha-2-macroglobulin, whereas the ratios for prealbumin, transferrin and IgG are slightly lower than those found in other studies on interstitial fluid [13,17,18]. |
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