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Polyneuropathy is a neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously. It may be acute and appear without warning, or chronic and develop gradually over a longer period of time. Many polyneuropathies have both motor and sensory involvement and some have autonomic dysfunction. These disorders are often symmetric and frequently involve distal extremities. There is a very large differential for polyneuropathy. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ...
The following codes are used with International Statistical Classification of Diseases and Related Health Problems. ...
The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ...
The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ...
Neurology is a branch of medicine dealing with disorders of the central and peripheral nervous systems. ...
The peripheral nervous system or PNS, is part of the nervous system, and consists of the nerves and neurons that reside or extend outside the central nervous system--to serve the limbs and organs, for example. ...
Evaluation Evaluation and classification of polyneuropathies begins with a history and physical exam in order to document what the pattern of the disease process is (arms, legs, distal, proximal, symmetric), when they started, how long they've lasted, if they fluctuate, and what deficits and pain are involved. If pain is a factor, and it often is, determining where and how long the pain has been present is important. 'The patient must be interviewed, and physical testing is often necessary to further delineate and document the pain. One also needs to know what disorders are already present within the family and what diseases the patient may currently have. This is vital in forming a differential diagnosis.
Diagnosis/testing Although often diseases are suggested by the physical exam and history alone, testing is still a large part of the diagnosis. Tests which may be employed include: electrodiagnostic testing using electromyography, muscle biopsy, serum creatine kinase (CK), antibody testing, . Nerve biopsy is not used much, but is helpful in determing small fiber neuropathy. Other tests may be used, especially tests for specific disorders associated with polyneuropathies. Electromyography (EMG) is a medical technique for evaluating and recording physiologic properties of muscles at rest and while contracting. ...
In medicine, a muscle biopsy is a procedure in which a piece of muscle tissue is removed from an organism and examined microscopically. ...
Creatine Kinase Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2. ...
Each antibody binds to a specific antigen; an interaction similar to a lock and key. ...
Small fiber peripheral neuropathy is a type of neuropathy. ...
Differential There is a large differential for polyneuropathies: vitamin deficiency, cancer, toxins, infections (ex. Guillain-Barré Syndrome), liver disease, endocrine disease (inc. diabetes with diabetic neuropathy), amyloidosis, genetic disorders, motor neuron disorders, motor neuropathies, kidney failure[1],paraneoplastic, polio, porphyria (some types), spinal muscular atrophy, catecholamine disorders, and many others. This is not a complete list. This article or section does not cite any references or sources. ...
Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ...
Guillain-Barré syndrome (GBS) is an acute, autoimmune, polyradiculoneuropathy affecting the peripheral nervous system, usually triggered by an acute infectious process. ...
The liver is an organ present in vertebrates and some other animals. ...
The endocrine system is a control system of ductless endocrine glands that secrete chemical messengers called hormones that circulate within the body via the bloodstream to affect distant organs. ...
This article is about the disease that features high blood sugar. ...
Diabetic neuropathies are neuropathic disorders that are associated with diabetes mellitus. ...
For a non-technical introduction to the topic, please see Introduction to genetics. ...
Renal failure is when the kidneys fail to function properly. ...
A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. ...
Poliomyelitis (polio), or infantile paralysis, is a viral paralytic disease. ...
It has been suggested that Acute intermittent porphyria be merged into this article or section. ...
Spinal Muscular Atrophy (SMA) is a term applied to a number of different disorders, all having in common a genetic cause and the manifestation of weakness due to loss of the motor neurons of the spinal cord and brainstem. ...
tyrosine epinephrine norepinephrine dopamine Synthesis This article or section does not cite its references or sources. ...
See also Neuropathy is usually short for peripheral neuropathy, meaning a disease of the peripheral nervous system. ...
Mononeuropathy (or mononeuritis) is a type of neuropathy that only affects a single peripheral or cranial nerve. ...
Polyneuropathy in dogs and cats is a collection of peripheral nerve disorders that often are breed-related in these animals. ...
Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ...
External links | Nervous system pathology (G) | | Inflammatory diseases of the central nervous system | Meningitis - Encephalitis - Myelitis - Encephalomyelitis (Acute disseminated) - Tropical spastic paraparesis | | Systemic atrophies primarily affecting the central nervous system | Huntington's disease - Spinocerebellar ataxia (Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic paraplegia) - Spinal muscular atrophy (Werdnig-Hoffman disease, Fazio Londe syndrome, Kugelberg-Welander disease, Motor neurone disease, Amyotrophic lateral sclerosis, Primary lateral sclerosis, Progressive bulbar palsy) | | Extrapyramidal and movement disorders | Parkinson's disease - Neuroleptic malignant syndrome - Postencephalitic parkinsonism - Pantothenate kinase-associated neurodegeneration - Progressive supranuclear palsy - Striatonigral degeneration - Dystonia (Spasmodic torticollis, Meige's syndrome, Blepharospasm) - Essential tremor - Myoclonus - Restless legs syndrome - Stiff person syndrome - Alzheimer's disease - Multiple sclerosis - Central pontine myelinolysis | | Episodic and paroxysmal disorders | Seizure/Epilepsy (Tonic-clonic seizure, Focal seizure, Complex partial seizure, Absence seizure, Atonic seizure, Lennox-Gastaut syndrome, West syndrome, Epilepsia partialis continua, Status epilepticus) - Headache (Migraine, Cluster, Vascular, Tension) - Amaurosis fugax - Foville's syndrome - Millard-Gubler syndrome - Lateral medullary syndrome - Weber's syndrome - Sleep disorder (Insomnia, Hypersomnia, Sleep apnea, Narcolepsy, Cataplexy) | | Nerve, nerve root and plexus disorders | Trigeminal neuralgia - Bell's palsy - Thoracic outlet syndrome - Phantom limb - Mononeuropathy (Carpal tunnel syndrome, Meralgia paraesthetica, Tarsal tunnel syndrome) | | Polyneuropathies and other disorders of the peripheral nervous system | Charcot-Marie-Tooth disease - Dejerine Sottas syndrome - Refsum's disease - Morvan's syndrome - Guillain-Barré syndrome - Polyneuropathy - Alcoholic polyneuropathy | | Diseases of myoneural junction and muscle | Myasthenia gravis - Muscular dystrophy - Myotonic dystrophy - Myotonia congenita - Thomsen disease - Neuromyotonia - Paramyotonia congenita - Centronuclear myopathy - Periodic paralysis (Hypokalemic, Hyperkalemic) - Lambert-Eaton myasthenic syndrome | | Cerebral palsy and other paralytic syndromes | Cerebral palsy - Paralysis - Hemiplegia - Spastic paraplegia - Paraplegia - Quadriplegia - Diplegia - Monoplegia - Cauda equina syndrome | | Other disorders of the nervous system | autonomic (Peripheral neuropathy, Familial dysautonomia, Horner's syndrome, Multiple system atrophy, Shy-Drager syndrome) - Hydrocephalus (Normal pressure) - Idiopathic intracranial hypertension - Encephalopathy - Brain herniation - Cerebral edema - Reye's syndrome - Syringomyelia - Syringobulbia - Spinal cord compression - Susac's syndrome - Krabbe disease - metachromatic leukodystrophy - adrenoleukodystrophy | |