Ponce de Leon Bay is a bay on the Gulf of Mexico in southwestern Florida in the United States. The bay is located in Monroe County at the northwestern end of Cape Sable in the Everglades National Park. Ponce de Leon Bay leads into Oyster Bay to the east, then into Whitewater Bay. The bay lies between Northwest Cape and Shark Point. It is named after Juan Ponce de León, a European explorer who was the first recorded European to reach Florida. Gulf of Mexico in 3D perspective. ... This article or section does not cite its references or sources. ... Location in the state of Florida Formed 1823 Seat Key West Area - Total - Water 9,679 km² (3,737 mi²) 7,097 km² (2,740 mi²) 73. ... Cape Sable, Florida is the southern most point of the US mainland and mainland Florida. ... Everglades National Park preserves the southern portion of the Everglades (all south of Tamiami Trail), but represents only 20 % of the original wetland area. ... Juan Ponce de León Juan Ponce de León (c. ...