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Encyclopedia > Prednisolone
Prednisolone
Systematic (IUPAC) name
11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydrocyclopenta [a]phenanthren-3-one
Identifiers
CAS number 50-24-8
ATC code A07EA01 C05AA04, D07AA03, D07XA02, H02AB06, R01AD02, S01BA04, S01CB02, S02BA03, S03BA02
PubChem 5755
DrugBank APRD00197
Chemical data
Formula C21H28O5 
Mol. mass 360.444 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 2-3 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links Download high-resolution version (1100x649, 38 KB) File links The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Prednisolone ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism A07A Intestinal anti-infectives A07AA Antibiotics A07AA01 Neomycin A07AA02 Nystatin A07AA03 Natamycin A07AA04 Streptomycin A07AA05 Polymyxin B A07AA06 Paromomycin A07AA07 Amphotericin B A07AA08 Kanamycin A07AA09 Vancomycin A07AA10 Colistin A07AA11 Rifaximin A07AA51 Neomycin, combinations A07AA54 Streptomycin, combinations... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Prednisolone is the active metabolite of prednisone. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... This article or section does not adequately cite its references or sources. ...


Prednisolone has an extremely bitter taste that makes it difficult to administer to children. Bitter can refer to: Bitter, one of the five basic tastes; Bitter, a kind of ale particularly popular in Britain or Bitters, a herbal preparation now used mostly in cocktails. ...


Uses

It is a corticosteroid drug with predominantly glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions such as asthma, rheumatoid arthritis, Ulcerative Colitis and Crohn's disease, multiple sclerosis, cluster headaches and Systemic Lupus Erythematosus. It can also be used as an immunosuppressive drug for organ transplants. Predisolone acetate opthamolic suspension is a sterile corticosteroid used to help to reduce swelling, redness, itching, and allergic reactions affecting the eye. In physiology, corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. ... Mineralocorticoids is a class of steroids characterised by their similarity to aldosterone and their influence on salt and water metabolism. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... Rheumatoid arthritis (RA) is traditionally considered a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. ... Crohns disease (also known as regional enteritis) is a chronic, episodic, inflammatory condition of the gastrointestinal tract characterized by transmural inflammation (affecting the entire wall of the involved bowel) and skip lesions (areas of inflammation with areas of normal lining in between). ... Cluster headaches are rare headaches that occur in groups or clusters. ... Immunosuppression is the medical suppression of the immune system. ... An organ transplant is the transplantation of an organ (or part of one) from one body to another, for the purpose of replacing the recipients damaged or failing organ with a working one from the donor. ...


Prescribed for treatment of Croup in toddlers.


Side effects

Possible side effects include fluid retention of the face (moon face, Cushing's Syndrome), acne, constipation and mood swings. Ocular Side-effects if taken; Constipation or irregularity, is a condition of the digestive system where a person (or animal) experiences hard feces that are difficult to eliminate; it may be extremely painful, and in severe cases (fecal impaction) lead to symptoms of bowel obstruction. ... A mood swing is an extreme change in mood. ...


Systemically: Posterior subcapsular cataracts & papilledema Papilledema is optic disc swelling that is caused by increased intracranial pressure. ...


Topical: PSC & glaucoma


Contraindicated with herpes Contraindicated is a medical term to indicate a situation in which a medication or treatment should not be administered. ... Genera Subfamily Alphaherpesvirinae    Simplexvirus    Varicellovirus    Mardivirus    Iltovirus Subfamily Betaherpesvirinae    Cytomegalovirus    Muromegalovirus    Roseolovirus Subfamily Gammaherpesvirinae    Lymphocryptovirus    Rhadinovirus Unassigned    Ictalurivirus The Herpesviridae are a family of DNA viruses that cause diseases in humans and animals. ...


  Results from FactBites:
 
Prednisolone - definition of Prednisolone in Encyclopedia (268 words)
Prednisolone is a synthetic corticosteroid drug which is usually taken orally and can be used for a large number of different conditions.
Prednisolone is particularly effective as an immunosuppressant and affects virtually all of the immune system.
For this reason, prednisolone cannot be stopped abruptly if taken for longer than seven days, but needs to be reduced slowly; this reduction may be over a few days if the course of prednisolone was short, but may take weeks or months if the patient has been on long-term steroid treatment.
  More results at FactBites »


 

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