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Encyclopedia > Progenitor cell

The term progenitor cell is used in cell biology and developmental biology to refer to immature or undifferentiated cells, typically found in post-natal animals. While progenitor cells share many common features with stem cells, the term is far less restrictive. Cell biology (also called cellular biology or formerly cytology, from the Greek kytos, container) is an academic discipline that studies cells. ... Views of a Foetus in the Womb, Leonardo da Vinci, ca. ... Drawing of the structure of cork as it appeared under the microscope to Robert Hook from Micrographia which is the origin of the word cell. POOP Cells in culture, stained for keratin (red) and DNA (green). ... Mouse embryonic stem cells with fluorescent marker. ...


Progenitor cells versus Stem cells

Like stem cells, progenitor cells have a capacity for self-renewal and differentiation, although these properties may be limited. This does not adequately cite its references or sources. ... Embryonic stem cells differentiate into cells in various body organs. ...

Feature Stem cell Progenitor Cell
Self-renewal Unlimited Can be limited
Plasticity Pluripotent Unipotent or Multipotent


Embryonic stem cells are true stem cells in that they are pluripotent and show unlimited capacity for self-renewal. In contrast, many cells termed adult stem cells would be better defined as progenitor cells, as their capacities for unlimited self renewal and plasticity have not been comprehensively demonstrated. Pluripotency in the broad sense refers to having more than one potential outcome. In biological systems, this can refer either to cells or to biological compounds. ... Unipotent cell, in cell biology, is used to describe a cell (e. ... Multipotent progenitor cells can give rise to several other cell types, but those types are limited in number. ... Mouse embryonic stem cells. ... Stem cell division and differentiation. ...


Function of Progenitor cells

The majority of progenitor cells lie dormant or possess little activity in the tissue in which they reside. They exhibit slow growth and their main role is to replace cells lost by normal attrition. Biological tissue is a group of cells that perform a similar function. ... The term cell growth is used in two different ways in biology. ...


Upon tissue damage or injury, progenitor cells can be activated by growth factors or cytokines, leading to increased cell division important for the repair process. Injury is damage or harm caused to the structure or function of the body caused by an outside agent or force, which may be physical or chemical. ... Growth factor is a protein that acts as a signaling molecule between cells (like cytokines and hormones) that attaches to specific receptors on the surface of a target cell and promotes differentiation and maturation of these cells. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ...


Examples of Progenitor cells


  Results from FactBites:
 
Cell infusions boost heart function, revive damaged heart muscle (621 words)
“The infusion of progenitor cells was associated with a reduction in the size of muscle damage, a significant improvement in pumping function, and less enlargement of the heart within four months after a heart attack,” said co-author Andreas M. Zeiher, M.D., chairman of the department of internal medicine at the University of Frankfurt in Germany.
The small study corroborates previous research that indicates stem and progenitor cells can reduce heart attack damage, and thus, the heart enlargement and failure that often follows.  The findings indicate that progenitor cell therapy enhances regeneration of the left ventricle after heart attack.
Neither the improvements in heart functioning nor the decrease in dead muscle correlated with the number of cells infused into a patient.  Instead, the team’s analysis indicated that the key to the improvements was the ability of cells to migrate from the artery into the heart muscle.
  More results at FactBites »


 

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