Progressive outer retinal necrosis (PORN), also known as Varicella zoster virus retinitis (VZVR)[1], is an aggressive, necrotizinginflammation of the eye's retina caused by herpes varicella zoster virus. It is typically found in people with advanced AIDS, but has also been reported in those who are severely immunocompromised due to chemotherapy[2]. Necrosis (in Greek ÎεκÏός = Dead) is the name given to unprogrammed death of cells and living tissue. ... Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ... Closeup of a blue-green human eye. ... Human eye cross-sectional view. ... The varicella-zoster virus (VZV), also known as human herpes virus 3 (HHV-3), is one of the eight herpes viruses known to affect humans (and other vertebrates). ... The Red ribbon is a symbol for solidarity with HIV-positive people and those living with AIDS. Acquired immunodeficiency syndrome or Acquired immune deficiency syndrome (AIDS or Aids) is a collection of symptoms and infections in humans resulting from the specific damage to the immune system caused by infection with... Chemotherapy is the use of chemical substances to treat disease. ...
The majority of those with progressive outer retinal necrosis develop severe vision loss and blindness[3]. Systemic antiviral drugs may improve the long-term visual outcome in those with the disease[1]. Visual loss results in the absence of vision where it existed before, which can happen either acutely (i. ... This article or section does not cite its references or sources. ... Antiviral drugs are a class of medication used specifically for treating viral infections. ...
References
^ ab Moorthy RS, Weinberg DV, Teich SA, Berger BB, Minturn JT, Kumar S, Rao NA, Fowell SM, Loose IA, Jampol LM. "Management of varicella zoster virus retinitis in AIDS." Br J Ophthalmol. 1997 Mar;81(3):189-94. PMID 9135381
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