Proinsulin is the substance made first in the pancreas that is then made into insulin. When insulin is purified from the pancreas of pork or beef, all the proinsulin is not fully removed. When some people use these insulins, the proinsulin can cause the body to react with a rash, to resist the insulin, or even to make dents or lumps in the skin at the place where the insulin is injected. The purified insulins have less proinsulin and other impurities than the other types of insulins. The structure can be found in Voet and Voet. Jump to: navigation, search The pancreas is a retroperitoneal organ that serves two functions: exocrine - it produces pancreatic juice containing digestive enzymes endocrine - it produces several important hormones // Anatomy The pancreas is a retroperitoneal organ located posterior to the stomach on the posterior abdominal wall. ... Jump to: navigation, search The structure of insulin Red: carbon; green: oxygen; blue: nitrogen; pink: sulfur. ...