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Encyclopedia > Propylhexedrine
Propylhexedrine
Systematic (IUPAC) name
N,α-dimethyl-cyclohexylethylamine
Identifiers
CAS number 3595-11-7
ATC code ??  ?
PubChem 7558
DrugBank ?
Chemical data
Formula C10H21N 
Mol. mass 155.29 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C Image File history File links Propylhexedrine. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... For other uses, see Carbon (disambiguation). ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, symbol, number nitrogen, N, 7 Chemical series nonmetals Group, period, block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... The biological half-life of a substance is the time required for half of that substance to be removed from an organism by either a physical or a chemical process. ... The kidneys are important excretory organs in vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status

Unscheduled (US Federal)
Schedule varies (US States)
Schedule V (Canada Exempted from the application of the CDSA The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...

Routes Nasal inhaler

Propylhexedrine, also known as hexahydrodesoxyephedrine or dimethylcyclohexaneethanamine, is a sympathomimetic with varied medicinal uses, is an adrenergic compound used mainly to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis. Being a vasoconstrictor used to decongest nasal mucosa, it is administered by inhalation. Propylhexedrine is most commonly found in over the counter Benzedrex inhalers. Benzedrex was first manufactured by Smith, Kline and French after the Benzedrine inhaler which contained amphetamine, became unavailable after the placement of amphetamines on Schedule II status (highest abuse potential of all legal drugs). In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body. ... Sympathomimetics are a class of drugs whose properties mimic those of a stimulated sympathetic nervous system. ... An adrenergic is a drug, or other substance, which has effects similar to, or the same as, epinephrine (adrenaline). ... In medicine, a disease is symptomatic when it is at a stage when the patient is experiencing symptoms. ... Rhinoviruses cause most common colds // Acute viral nasopharyngitis, or acute coryza, usually known as the common cold, is a highly contagious, viral infectious disease of the upper respiratory system, primarily caused by picornaviruses or coronaviruses. ... Allergy is an abnormal reaction to a substance foreign to the body that is acquired, predictable and rapid. ... Rhinitis is the medical term describing irritation and inflammation of the nose. ... Vasoconstriction is the constriction of blood vessels, in other words, when the lumen narrows. ... Over-the-counter substances, also abbreviated OTC, are drugs and other medical remedies that may be sold without a prescription and without a visit to a medical professional, in contrast to prescription only medicines (POM). ... GlaxoSmithKline (GSK) plc is a pharmaceutical and healthcare company, one of the largest in the world, in fact the second largest pharmaceutical company. ... This article does not cite any references or sources. ... Amphetamine or Amfetamine(Alpha-Methyl-PHenEThylAMINE), also known as beta-phenyl-isopropylamine and benzedrine, is a prescription stimulant commonly used to treat Attention-deficit hyperactivity disorder (ADHD) in adults and children. ...

Contents

Recreational use

These inhalers have been occasionally used by people for their stimulant effects which are believed by some to be similar to methamphetamine. This is done by removing the cotton rod from the inhaler and performing a cold-water extraction, or just mixing it with soda, though occasionally some swallow it. Each cotton contains 250 mg (quarter-gram) of propylhexedrine. Stimulants are drugs that temporarily increase alertness and wakefulness. ... This article is about the psychostimulant, d-methamphetamine. ... “Kg” redirects here. ...


Propylhexedrine is of significantly less risk of being used recreationally than amphetamines. This is primarily because propylhexedrine has limited methods of use, unlike amphetamines. The abuse potential is low enough that neither the DEA nor the WHO consider it a drug of concern, unlike ephedrine or its salts. However, attempts to extract the drug from the nasal inhaler and then inject it have been known. Abuse by injection is dangerous and could result in death, which has been recorded.[1] [2] The DEAs enforcement activities may take agents anywhere from distant countries to suburban U.S. homes. ... Look up who in Wiktionary, the free dictionary. ... Ephedrine (EPH) is a sympathomimetic amine similar in structure to the synthetic derivatives amphetamine and methamphetamine. ...


As with similar drugs, using propylhexedrine to keep oneself awake for extended amounts of time can lead to a temporary state of sleep deprivation psychosis during which an individual may experience hallucinations of all kinds as well as extreme paranoia, all common effects associated with sleep deprivation. The effect supposedly is "body tingles", which are simply waves of sensation that flow throughout various parts of the body. Some consider these tingles to be pleasurable, but not euphoric. The most sought-after effect is a general state of well-being and happiness associated with stimulants. However, this effect is not as pronounced as that delivered by more commonly abused stimulants such as methamphetamine or cocaine. Sleep deprivation is a general lack of the necessary amount of sleep. ... Psychosis is a generic psychiatric term for a mental state often described as involving a loss of contact with reality. Stedmans Medical Dictionary defines psychosis as a severe mental disorder, with or without organic damage, characterized by derangement of personality and loss of contact with reality and causing deterioration... A hallucination is a false sensory perception in the absence of an external stimulus, as distinct from an illusion, which is a misperception of an external stimulus. ... For other senses of this word, see paranoia (disambiguation). ... Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. ...


The effects vary from person to person. Many people suffer adverse effects after using the drug, feeling sick and nauseated. It is a vasoconstrictor, so ingestion can cause nausea and serious gastrointestinal issues. As with similar stimulants, it is possible to overdose on the substance. For other uses, see Nausea (disambiguation). ...


Eating cotton for any reason is not a healthy practice, and though not necessarily fatal, can still lead to gastrointestinal problems. For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and...


Chemistry

Propylhexedrine is structurally similar to methamphetamine. The only difference is that the phenyl group of the methamphetamine molecule is swapped with a cyclohexyl group. It is because of this that propylhexedrine is not an amphetamine, nor even a phenethylamine. It is most like methamphetamine in terms that it contains a methyl (CH3) group in positions Rα and RN. This article is about the psychostimulant, d-methamphetamine. ... In chemistry, the phenyl group or phenyl ring (often abbreviated as -Ph) is the functional group with the formula -C6H5 Picture where the six carbon atoms are arranged in a cyclic manner. ... Cyclohexane is a cycloalkane with the molecular formula C6H12. ... Phenethylamine, or β-Phenylethylamine, is an alkaloid and monoamine. ... This article is about the psychostimulant, d-methamphetamine. ... In chemistry a methyl-group is a hydrophobic Alkyl functional group which is derived from methane (CH4). ...


See also

Amphetamine or Amfetamine(Alpha-Methyl-PHenEThylAMINE), also known as beta-phenyl-isopropylamine and benzedrine, is a prescription stimulant commonly used to treat Attention-deficit hyperactivity disorder (ADHD) in adults and children. ... Cyclopentamine is a stimulant drug structurally related to methamphetamine, wherein the aromatic phenyl ring is replaced with a cyclopentane ring. ... This article is about the psychostimulant, d-methamphetamine. ... Ephedrine (EPH) is a sympathomimetic amine similar in structure to the synthetic derivatives amphetamine and methamphetamine. ... In chemistry, the phenyl group or phenyl ring (often abbreviated as -Ph) is the functional group with the formula -C6H5 Picture where the six carbon atoms are arranged in a cyclic manner. ... Cyclohexane is a cycloalkane with the molecular formula C6H12. ... Phenethylamine, or β-Phenylethylamine, is an alkaloid and monoamine. ... This article does not cite any references or sources. ...

Notes

  1. ^ "Proposed Rules". Federal Register 50 (10): 2226 – 2227. 
  2. ^ Prince v. Ascher,   90 P.3d 1020 (2004)

  Results from FactBites:
 
Benzedrex Inhaler Propylhexedrine Nasal Decongestant - 1 Ea (129 words)
Benzedrex Inhaler Propylhexedrine Nasal Decongestant - 1 Ea E-mail: admin@darisimall.com
Benzedrex Inhaler Propylhexedrine Nasal Decongestant temporarily relieves nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis).
This inhaler is effective for a minimum of 3 months after first use.
Gingival retraction cords incorporating propylhexedrine - Patent 6375461 (6464 words)
Although propylhexedrine is the preferred vasoconstrictor for use with the retraction cords of the present invention, it is within the scope of the invention to include other vasoconstrictors in addition to propylhexedrine, or in place of a portion of the propylhexedrine, in order to provide further hemostasis and/or gum stiffening effect.
In a preferred embodiment, the propylhexedrine is in the form of propylhexedrine hydrochloride, which is dissolved in water or a mixture of water and alcohol (e.g., ethyl alcohol or isopropyl alcohol).
The concentration of propylhexedrine hydrochloride (or other desired form of propylhexedrine) in the retraction cord, which is typically measured in milligrams per inch (mg/in.), will generally be a function of the concentration of the propylhexedrine solution as well as the thickness or diameter of the retraction cord.
  More results at FactBites »


 

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