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prostaglandin: Definition and Much More From Answers.com (1376 words) |
 | The prostaglandins together with the thromboxanes form the prostanoid class of fatty acid derivatives; the prostanoid class is a subclass of eicosanoids. |
| The cyclooxygenase pathway produces thromboxane, prostacyclin and prostaglandin D, E and F. The lipoxygenase pathway is active in leukocytes and in macrophages and synthesises leukotrienes. |
| Prostaglandins thus act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. |
| 3-Hydroxy and 3-oxo-prostaglandin analogues - Patent 4351846 (4541 words) |
| A prostaglandin analogue according to claim 1 wherein the grouping --R.sup.2 --R.sup.3 represents n-pentyl, 1-methylpentyl, 2-methylpentyl, 1,1-dimethylpentyl, n-hexyl, 2-methylhexyl, cyclopentyl, cyclopentylmethyl, 2-cyclopentylethyl, 3-ethylcyclopentyl, 3-propylcyclopentyl, 3-butylcyclopentyl, cyclohexyl, cyclohexylmethyl, 2-cyclohexylethyl, 4-methylcyclohexyl, 4-propylcyclohexyl, benzyl, 2-phenylethyl, phenoxymethyl, 3-chlorophenoxymethyl, 4-chlorophenoxymethyl or 3-trifluoromethylphenoxymethyl. |
| A prostaglandin analogue according to claim 1 wherein the group OR.sup.6 attached to the C-15 carbon atoms in formula IV depicted in claim 1 is in.alpha.-configuration. |
| A prostaglandin analogue according to claim 1 wherein R.sup.6 represents a hydroxy-protecting group which may be removed under mild acidic conditions and the other symbols are as defined in claim 1. |
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