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Encyclopedia > Prostanoid

Prostanoid is the term used to describe three classes of eicosanoids: the prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction) and the prostacyclins (active in the resolution phase of inflamation.) In biochemistry, eicosanoids are a class of oxygenated hydrophobic cytokines that largely function as a autocrine and paracrine mediators. ... A prostaglandin is any member of a group of lipid compounds that are derived from fatty acids and have important functions in the animal body. ... Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ... Anaphylaxis is a severe and rapid systemic allergic reaction to a trigger substance, called an allergen. ... Thromboxane is a member of the family of lipids known as eicosanoids. ... The blood vessels are part of the circulatory system and function to transport blood throughout the body. ... Prostacyclin is a member of the family of lipid molecules known as eicosanoids. ...


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Genomics|HuGENet|e-Journal|Prostanoid DP and asthma (823 words)
Models in mice suggest that functional gene variants of the prostanoid DP receptor (PTGDR) are required for the expression of asthma.
Matsuoka showed mice that do not have a functional prostanoid DP receptor were not able to express asthma (5).
Role of prostanoid DP receptor variants in susceptibility to asthma.
Prostanoid Receptors: Structures, Properties, and Functions -- Narumiya et al. 79 (4): 1193 -- Physiological Reviews (9103 words)
prostanoid receptors induced by phorbol esters was examined in
Phylogenetic tree of prostanoid receptors was constructed by sequence comparison of prostanoid receptors from various species.
affinities of carboxy methyl esters of prostanoid molecules to
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