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Encyclopedia > Psychotropic drug

A psychoactive drug or psychotropic substance is a chemical that alters brain function, resulting in temporary changes in perception, mood, consciousness, or behaviour. Such drugs are often used for recreational and spiritual purposes, as well as in medicine, especially for treating neurological and psychological illnesses.

Contents

Common psychoactive drugs

Note: This overview groups together drugs with different effects and modes of action. Several have properties of many categories.

Ways Psychoactive Drugs Affect The Brain

There are many ways in which psychoactive drugs can affect the brain. While some drugs affect neurons presynaptically, others act postsynpatically and some drugs don't even attack the synapse, working on neural axons instead. Here is a general breakdown of the ways psychoative drugs can work.

  1. Prevent The Action Potential From Starting
    • Lidocaine, TTX (they bind to voltage-gated sodium channels, so no action potential begins even when a generator potential passes threshold)
  2. NT Synthesis
    • Increase - L-Dopa, tryptophan, choline (precursors)
    • Decrease - PCPA (inhibits synthesis of 5HT)
  3. NT Packaging
    • Increase - MAO Inhibitors
    • Decreasing - Resperine (pokes holes in the synaptic vesicles of catecholamines)
  4. NT Release
    • Increase - Black Widow Spider (Ach)
    • Decrease - Botulinum Toxin (Ach), Tetanus (GABA)
  5. Agonists - Mimick the original NTs and activate the receptors
    • Muscuraine, Nicotine (Ach)
    • AMDA, NMDA (Glu)
    • Alcohol, Benzodiazepines (GABA)
  6. Antagonists - Bind to the receptor sites and block activation
    • Atropine, Curare (Ach)
    • PCP (Glu)
  7. Prevent Ach Breakdown -
    • Insecticides, Nerve Gas
  8. Prevent Reuptake
    • Cocaine (DA), Amphetamines (E)
    • Tricyclics, SSRIs

(NT = Neurotransmitter)


- based on information taught in NSC 201, Vanderbilt University


Related articles

External links

  • Erowid (http://www.erowid.org/)
  • Spirit Plants (http://www.spiritplants.com/)
  • Psychotropic Drug Advisory Service (http://www.mhri.edu.au/pda/)
  • Drug Wise Newsletter: A Newsletter on Psychotropic Drugs (http://home.vicnet.net.au/~drugwise/drugwise.htm)

  Results from FactBites:
 
BioMed Central | Full text | Factors associated with psychotropic drug use among community-dwelling older persons: A ... (7947 words)
Psychotropic drugs are defined as substances that act directly on the central nervous system, affecting mood, cognition, and behavior, and usually include anxiolytics, sedatives and hypnotics, antidepressants, neuroleptics, anticonvulsants, and stimulants.
Notable harmful consequences of psychotropic drug use include memory impairment, psychomotor slowing, delirium, falls with a risk of hip fracture, automobile accidents, and psychiatric hospitalizations [19-21].
Psychotropic drug users were 2.78 times more likely to report depressive symptoms at 6-year follow-up [68], and 4 times more likely to report anxious or depressive symptoms [94] (Table 3).
Correctional Service of Canada - Epidemiological Study on Psychotropic Drug Use among Female Inmates (1137 words)
The objective of this exploratory research was to obtain data on psychotropic drug use among female offenders and inmates.
Specifically, its purpose was to define the drug use profile of this clientele (identify the extent of drug use, the types of substances used and the extent of drug use problems) and do an inventory of the available intervention options in the judicial system.
Finally, in light of the difficult psychotropic drug use problem, it is of primary importance that penal institutions be receptive to the needs of female offenders and encourage communication and helping relationships for this clientele in order to improve their situation.
  More results at FactBites »


 

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