Isabella of Portugal (1503-1539) (queen consort), daughter of Manuel I of Portugal, wife of Charles V, Holy Roman Emperor (External link to portrait (http://costume.dm.net/gallery/brownvelvet.html))
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Isabella I of Castile (1451-1504) (queen regnant), wife of Ferdinand II of Aragon, mother of Catherine of Aragon, patron of Christopher Columbus
Isabella of Portugal, or Isabella of Asturias, (1470-1498) (queen consort), daughter of Isabella I of Castile and Ferdinand II of Aragon, wife of Manuel I of Portugal
Isabella II of Spain (1830-1904) (queen regnant), daughter of Ferdinand VII of Spain, mother of Alfonso XII of Spain
Isabella I, Queen of Castile, was born in the town of Madrigal de las Altas Torres April 22, 1453 and died a little before noon November 26, 1504 in the castle of La Mota, which still stands at Medina del Campo (Valladolid).
The year before Isabella had been living at Segovia, apart from the court, which resided at Toledo; after the conclusion of the pact she was at odds with her brother, the king on account of his plans for her marriage.
Isabella, as soon as she was left alone, journeyed to Valladolid, and from there sent loyal followers in search of Ferdinand, who had been proclaimed King of Sicily and heir of the Aragonese monarchy.