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Encyclopedia > Reuptake

Reuptake, or re-uptake, is the reabsorption of a neurotransmitter by the neurotransmitter transporter of a pre-synaptic neuron after it has performed its function of transmitting a neural impulse. This prevents further activity of the neurotransmitter, weakening its effects. Chemical structure of D-Aspartic Acid, a common Amino Acid neurotransmitter. ... Neurotransmitter transporters are proteins that span cellular membranes and that serve to carry neurotransmitters across these membranes and to transport them to specific locations. ... Illustration of the major elements in a prototypical synapse. ... Drawing by Santiago Ramón y Cajal of neurons in the pigeon cerebellum. ... A. A schematic view of an idealized action potential illustrates its various phases as the action potential passes a point on a cell membrane. ...


As an example, serotonin is a neurotransmitter. It is produced by cells in the brain and is used by nerves to communicate with one another. A nerve releases the serotonin that it has produced into the space surrounding it. The serotonin either travels across that space and attaches to receptors on the surface of nearby neuron or it attaches to receptors on the surface of the neuron that produced it, to be taken up by the neuron, recycled, and released again. This process is referred to as reuptake. A balance is reached for serotonin between attachment to the nearby neurons and reuptake. A medication that acts as a selective serotonin reuptake inhibitor (SSRI) blocks the reuptake of serotonin and thereby increases the level of serotonin in the brain. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesized in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells in the gastrointestinal tract of animals including humans. ... Drawing of the structure of cork as it appeared under the microscope to Robert Hook from Micrographia which is the origin of the word cell. POOP Cells in culture, stained for keratin (red) and DNA (green). ... In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates the cellular response to the ligand. ... Serotonin Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants used in the treatment of depression, anxiety disorders and some personality disorders. ... Italic text // ahh addiing sum spiice iin hurr`` For other uses, see Brain (disambiguation). ...


When a neuron's receptor cells are blocked by neural inhibitors, all of it is forced to be released into the bloodstream, increasing the levels. Popular SSRIs like sertraline and fluoxetine do this, causing the serotonin to be collected by the receptor cells and overall increasing the levels of the neurotransmitter. “Lustral” redirects here. ... Fluoxetine hydrochloride (Prozac) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. ...


  Results from FactBites:
 
Reuptake - Wikipedia, the free encyclopedia (212 words)
Reuptake is the reabsorption of a neurotransmitter by the molecular transporter of a pre-synaptic neuron after it has performed its function of transmitting a neural impulse.
Reuptake: The reabsorption of a secreted substance by the cell that originally produced and secreted it.
The serotonin either travels across that space and attaches to receptors on the surface of nearby nerves or it attaches to receptors on the surface of the nerve that produced it, to be taken up by the nerve, recycled, and released again.
Serotonin-norepinephrine reuptake inhibitor - Wikipedia, the free encyclopedia (555 words)
Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders.
Activity on norephinephine reuptake is thought necessary for an antidepressant to be effective on neuropathic pain, a property shared with the older tricyclic antidepressants but not with the SSRIs.
After firing, most of the neurotransmitter is reabsorbed by the presynaptic cell in a process called reuptake.
  More results at FactBites »


 

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