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Rheb - Wikipedia, the free encyclopedia (77 words) |
 | Rheb, in molecular biology, is a protein, a recently discovered member of the Ras superfamily that may be involved in neural plasticity. |
| This function is novel and not typically associated with the Ras proteins. |
| The name Rheb is short for Ras homolog enriched in brain. |
| Rheb (2303 words) |
| Overexpression of Rheb in the developing fly causes dramatic overgrowth of multiple tissues: in the wing, this is due to an increase in cell size; in cultured cells, Rheb overexpression results in accumulation of cells in S phase and an increase in cell size. |
| Rheb is required in the whole organism for viability (growth) and for the growth of individual cells. |
| Consistent with this interpretation, flies with reduced Rheb activity are hypersensitive to rapamycin, an inhibitor of the growth regulator target of rapamycin (TOR), a kinase required for growth factor-dependent phosphorylation of ribosomal S6 kinase (S6K). |
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