He was born in Peoria, Illinois. He attended the Harvard Military School in Los Angeles, California. Upon his graduation, Whiting began his career as a staff writer for various music publishers. In 1912, he became a personal manager.
In 1919, he moved to Hollywood and wrote a number of film scores. He wrote music, collaborating with such lyricists as BG DeSylva, Ray Egan, Johnny Mercer, Neil Moret, Leo Robin, Gus Kahn, and Sidney Clare, to produce a number of hits (listed below). He also wrote a number of scores for Broadway plays.