Risk and Safety Statements, also known as R/S statements, R/S numbers, R/S phrases, and R/S sentences, is a system of hazard codes and phrases for labeling dangerous chemicals and compounds. The R/S statement of a compound consists of a risk part (R) and a safety part (S), each followed by a combination of numbers. Each number corresponds to a phrase. Hazard is a term used in evaluating safety: A hazard is a potential unwanted event. ... A chemical substance is any material substance used in or obtained by a process in chemistry: A chemical compound is a substance consisting of two or more chemical elements that are chemically combined in fixed proportions. ...
Example
The R/S statement code for fuming hydrochloric acid (37%) is: The chemical substance hydrochloric acid is the aqueous (water-based) solution of hydrogen chloride (HCl) gas. ...
R: 34-37 S: 26-36-45
The corresponding phrases are:
Risks
R: 34 Causes burns
R: 37 Irritating to the respiratory system.
Safety
S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S: 36 Wear suitable protective clothing.
S: 45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
Dashes separate the phrase numbers. They are not to be confused with range indicators.
Example: R: 34-37 Causes burns, irritating to the respiratory system.
Slashes indicate fixed combinations of single phrases.
Example: R: 36/37/38 Irritating to eyes, respiratory system and skin.
More detailed hazard and safety information can be found in the material safety data sheets (MSDS) of a compound. A material safety data sheet or MSDS is a form containing data regarding the properties of a particular substance. ...
Risk and SafetyStatements, also known as R/S statements, R/S numbers, R/S phrases, and R/S sentences, is a system of hazard codes and phrases for labeling dangerous chemicals and compounds.
The R/S statement of a compound consists of a risk part (R) and a safety part (S), each followed by a combination of numbers.
More detailed hazard and safety information can be found in the material safety data sheets (MSDS) of a compound.
Although there are potential benefits to be derived from participation in clinical research, the IRBs and the NIH must ensure, to the extent possible, the safety of study participants and that they do not incur undue risk and that the risks versus benefits are continually reassessed throughout the study period.
Oversight of monitoring must be done to ensure that data and safety monitoring plans are in place for all interventional trials, that the quality of these monitoring activities is appropriate to the trial(s), and that the IC has been informed of recommendations that emanate from monitoring activities.
While short-term risk is usually slight, one must consider the long term effects of a study agent or achievement of significant safety or efficacy differences between the control and study groups for a masked study.
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