Route 21 Length: Image File history File links Missouri_21. ... 188 mi (304 km) Established: 1922 Decommissioned: Present Direction: North-South From: Affton To: Arkansas state line Cities on route: Affton Lakeshire Green Park Concord Otto Hillsboro De Soto Old Mines Potosi Caledonia Belleview Pilot Knob Ironton Arcadia Lesterville Centerville Ellington Hunter Grandin Doniphan Poynor

Route 21 is a highway in eastern Missouri. Its northern terminus is at Route 30 in Affton. Its southern terminus is at the Arkansas state line (where it continues as Highway 115). In the St. Louis area, it is known as Tesson Ferry Road, which was named after the nineteenth century proprietor of the ferry across the Meramec River. Tesson Ferry is also right through the heart of SOCO, a term used by the teenagers of this region to abbreviate South County. Affton is an unincorporated census-designated place located in St. ... Official language(s) English Capital Little Rock Largest city Little Rock Area  Ranked 29th  - Total 53,179 sq mi (137,732 km²)  - Width 239 miles (385 km)  - Length 261 miles (420 km)  - % water 2. ... Affton is an unincorporated census-designated place located in St. ... Lakeshire is a city located in St. ... Green Park is a city located in St. ... Concord is a census-designated place located in St. ... Hillsboro is a city located in Jefferson County, Missouri. ... De Soto is a city located in Jefferson County, Missouri. ... Potosi is a city located in Washington County, Missouri. ... Caledonia is a village located in Washington County, Missouri. ... Belleview is an unincorporated community in northern Iron County, Missouri. ... Pilot Knob is a city located in Iron County, Missouri. ... Ironton is a city located in Iron County, Missouri. ... Arcadia is a city located in Iron County, Missouri. ... Lesterville, Missouri is an unincorporated community in southeast Missouri. ... Centerville is a city located in Reynolds County, Missouri. ... Ellington is a city located in Reynolds County, Missouri. ... Hunter is an unincorporated community in Carter County, Missouri. ... Grandin is a city located in Carter County, Missouri. ... Doniphan is a city located in Ripley County, Missouri. ... Poynor is an unincorporated community in southern Ripley County, Missouri about two miles north of the Arkansas state line. ... This article does not cite its references or sources. ... Affton is an unincorporated census-designated place located in St. ... Official language(s) English Capital Little Rock Largest city Little Rock Area  Ranked 29th  - Total 53,179 sq mi (137,732 km²)  - Width 239 miles (385 km)  - Length 261 miles (420 km)  - % water 2. ... The Meramec River Looking North from Route 66 State Park Canoers enjoy a float trip on the Meramec below Leasburg The Meramec River is the longest free-flowing waterway in Missouri -- it wanders some 350 kilometers (220 miles) through six Missouri Ozark Highland counties: Dent, Phelps, Crawford, Franklin, Jefferson, and...

The section through northern Jefferson County, Missouri was the site of numerous fatal traffic accidents due to the narrow road being unable to handle increased traffic from population growth, and was referred to as "Blood Alley" and "Missouri's Most Dangerous Highway" (and was featured in an Reader's Digest article on dangerous roads)^{[citation needed]}. As a result, the road was rerouted and built to freeway standards; it is currently freeway standard to just north of Hillsboro, Missouri and construction is underway to eventually re-route the road to just south of Hillsboro. Jefferson County is a county located in the state of Missouri, and included the mean center of U.S. population in 1980. ... This article or section does not cite its references or sources. ... It has been suggested that Autobahn be merged into this article or section. ... Hillsboro is a city located in Jefferson County, Missouri. ...