Route 22 Length: 23 mi (37 km) Established: 1922 Decommissioned: Present Direction: East-West From: Mexico To: South of Clark Cities on route: Mexico Centralia

Route 22 is a highway in central Missouri. Its eastern terminus is at Route 15 in Mexico; its western terminus is at U.S. Highway 63 south of Clark on the Randolph/Boone county line. Missouri 22 was one of the original 1922 state highways and originally had an eastern terminus at Route 9 (now U.S. Route 61) in Louisiana. This section was replaced by U.S. Route 54. Clark is a city located in Randolph County, Missouri. ... Centralia is a city located in Boone County, Missouri. ... This article does not cite its references or sources. ... United States Highway 63 is an north-south United States highway that runs for 1,286 miles (2,070 km) from northern Wisconsin to northern Louisiana. ... Clark is a city located in Randolph County, Missouri. ... Randolph County is a county located in the state of Missouri. ... Boone County is a county located in the U.S. state of Missouri. ... The Dubuque-Wisconsin Bridge, Dubuque, Iowa. ... Louisiana is a city located in Pike County, Missouri. ... U.S. Highway 54 is an east-west United States highway that runs northeast-southwest for 1,197 miles (1,926 km) from western Illinois to El Paso, Texas. ...