Route 72 Length: 157 mi (251 km) Established: 1922 Decommissioned: Present Direction: East-West From: West of Jackson To: Rolla Cities on route: Millersville Fredericktown Oak Grove Roselle Ironton Arcadia Lesterville Centerville Reynolds Bunker Salem Lake Spring Rolla

Route 72 is a highway in southern Missouri. Its eastern terminus is at Route 34 west of Jackson; its western terminus is at U.S. Highway 63 in Rolla. Jackson is a city located in Cape Girardeau County, Missouri. ... Rolla is a city located in Phelps County, Missouri. ... Millersville is an unincorporated community in western Cape Girardeau County, Missouri. ... Fredericktown is a city located in Madison County, Missouri, United States. ... Oak Grove is an unincorporated community in Madison County, Missouri. ... Ironton is a city located in Iron County, Missouri. ... Arcadia is a city located in Iron County, Missouri. ... Lesterville, Missouri is an unincorporated community in southeast Missouri. ... Centerville is a city located in Reynolds County, Missouri. ... Reynolds is an unincorporated community in western Reynolds County, Missouri. ... Bunker is a city located in Dent and Reynolds County, Missouri. ... Salem is a city located in Dent County, Missouri. ... Rolla is a city located in Phelps County, Missouri. ... This article does not cite its references or sources. ... Jackson is a city located in Cape Girardeau County, Missouri. ... United States Highway 63 is an north-south United States highway that runs for 1,286 miles (2,070 km) from northern Wisconsin to northern Louisiana. ... Rolla is a city located in Phelps County, Missouri. ...

Missouri 72 is one of the original 1922 state highways. Its eastern terminus was at Centerville, its western terminus was at the junction with Route 32.