He broke with the Bolsheviks in 1910 over the faction's rejection of a proposal to reunite the RDSPL, but remained active in the Moscow Soviet and called for the creation of a left wing coalition.
In the new Bolshevik government he became People's Commissar of the Interior until 1918 but broke with the Bolsheviks when the call for a coalition government was rejected. He soon returned took on economic portfolios. He also served on the Revolutionary Military Council during the Russian Civil War. He succeeded Lenin as premier in 1924 and supported Stalin and Bukharin against Leon Trotsky. Rykov was on the "right" of the party and a supporter of the New Economic Policy. When Stalin broke with Bukharin and the right, Rykov was removed from his positions.
He fell into obsurity until 1938 when, as part of the Great Purge, he was put on trial with Bukharin, Yagoda, Rakovsky and Krestinsky for allegedly plotting with Trotsky against Stalin. He was found guilty in a show trial and executed on March 15, 1938.
Rykov supported the New Economic Policy initiated by Lenin and found an unexpected ally in the person of Iosif Stalin, who joined Rykov in advocating an economic policy that encouraged the development of a prosperous agricultural sector that would finance industrialization.
Rykov's ultimate defeat occurred in December 1930, when Stalin orchestrated his dismissal from all important party and state posts including chairmanship in the USSR government (19 Dec 1930) and membership in the Politburo (21 Dec 1930).
In 1936 Rykov was falsely accused of plotting against the Soviet state and Communist leadership by the defendants of the Zinovyev-Kamenev show trial.
He joined Stalin in the 1926 polemical struggle which saw the humbling of Zinoviev and Kamenev and the exile of Trotsky.
Rykov was in turn accused (1929) of "rightist deviation" when Stalin switched camps and advocated a drastic collectivization program, which Rykov had opposed.
Rykov was forced to admit his "errors" and was expelled from the Politburo; Molotov succeeded him as premier.