Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD. It is currently available in both dry-powder inhalers (DPIs) and pressurised metered dose inhalers (pMDIs). Beta2-adrenergic receptor agonists are a class of drugs used to treat asthma. ... Look up drug in Wiktionary, the free dictionary. ... Chronic obstructive pulmonary disease (COPD) is an umbrella term for a group of respiratory tract diseases that are characterised by airflow obstruction or limitation. ...
It is a long acting beta-adrenoceptor agonist (LABA), usually only prescribed for severe persistent asthma following previous treatment with a short-acting beta agonist such as salbutamol and is prescribed concurrently with a corticosteroid, such as beclometasone. The primary noticable difference of salmeterol to salbutamol is that the duration of action lasts approximately 12 hours in comparison with 4-6 hours of salbutamol. Long acting beta-adrenoceptor agonists include formoterol, salmeterol and are usually prescribed for moderate to severe persistent asthma patients or patients with COPD. They are designed to replace the shorter acting B2-agonists such as salbutamol, as they have a duration of action of approximately 12 hours in comparison with... Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD. It is marketed by the Allen & Hanburys respiratory division of GlaxoSmithKline under the trade name Ventolin. ... Beclometasone is an inhaled corticosteroid drug for the use of prophylaxis of asthma. ... Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD. It is marketed by the Allen & Hanburys respiratory division of GlaxoSmithKline under the trade name Ventolin. ...
When used regularly every day as prescribed, inhaled formoterol decreases the number and severity of asthma attacks. However, it is not for use for relieving an asthma attack that has already started.
Inhaled salmeterol works like other beta 2-agonists, causing bronchodilatation by relaxing the smooth muscle in the airway so as to treat the exacerbation of asthma. The long duration of formoterol action occurs by the formoterol molecules initially diffusing into the plasma membrane of the lung cells, and then slowly being released back outside the cell where they can come into contact with the beta-2 adrenoceptors. Formoterol has been demonstrated to have a faster onset of action than salmeterol as a result of a lower lipophilicity, and has also been demonstrated to be more potent - a 12µg dose of formoterol has been demonstrated to be equivalent to a 50µg dose of salmeterol. Formoterol belongs to the family of prescription-only medicines known as beta 2-agonists. ...
Salmeterol was developed by the company GlaxoSmithKline in the 1980's and was released as Serevent in 1990. GlaxoSmithKline plc (LSE: GSK NYSE: GSK) is a British based pharmaceutical, biologicals, and healthcare company. ...
Salmeterol is an inhaled medication that blocks the release of histamine by the mast cells, thus preventing airway narrowing when exposed to allergens.
Therefore, salmeterol is useful in patients that require frequent administration of short acting beta-2 agonists, such as albuterol, for control of their asthma symptoms.
Salmeterol is metabolized by the liver and should be used with caution in patients with liver dysfunction.
Salmeterol is similar in structure to salbutamol except that it has the addition of a long non-polar side chain.
Salmeterol has been shown to protect against bronchoconstriction caused by histamine, methacholine and exercise, and in suppressing late phase bronchoconstriction suggesting that it has some degree of anti-inflammatory activity in addition to its bronchodilator role.
Salmeterol is rapidly absorbed from the lung and is rapidly eliminated with a plasma half life of between 2-8 hours.
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