Seine River is a provincial electoral division in the Canadian province of Manitoba. It was created by redistribution in 1989, and has formally existed since the provincial election of 1990. The riding is located in the southern section of the City of Winnipeg.

Seine River is bordered to the south and east by the rural riding of La Verendrye, to the north by Southdale and Riel, and to the west by St. Norbert. The riding is mostly urban, although it also includes some rural space.

The riding's population in 1996 was 18,833. As of 1999, the average family income was $63,800, and the unemployment rate was 4.20%. Seine River's francophone population is 9%, and there is also a significant German community (4%). Health and social services account for 14% of the riding's industry.

Seine River was represented by Louise Dacquay of the Progressive Conservative Party from 1990 to 2003, when the New Democratic Party won the seat for the first time. Seine River's current MLA is Theresa Oswald.

List of provincial representatives