FACTOID # 54: The Mall in Washington, D.C. is 1.4 times larger than Vatican City.
 
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Encyclopedia > SiRNA

Small interfering RNA (siRNA) are a class of 20-25 nucleotide-long RNA molecules that interfere with the expression of genes. These are produced as part of the RNA interference (RNAi) process by the enzyme Dicer.


External links

  • siDirect: a web-based online software system for computing siRNA sequences (http://design.rnai.jp/)
  • Paper describing siDirect (http://nar.oupjournals.org/cgi/content/full/32/suppl_2/W124)
  • Paper describing effectivity of siDirect (http://nar.oupjournals.org/cgi/content/full/32/3/936)

  Results from FactBites:
 
AG 105 Tuschl: siRNA (3337 words)
1999), we have systematically analyzed the silencing efficiency of siRNA duplexes as a function of the length of the siRNAs, the length of the overhang and the sequence in the overhang (Elbashir et al.
The rationale for this sequence conversion is to generate a symmetric duplex with respect to the sequence composition of the sense and antisense 3' overhangs.
The antisense siRNA is synthesized as the complement to position 1 to 21 of the 23-nt motif.
Small interfering RNA - Wikipedia, the free encyclopedia (1319 words)
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of 20-25 nucleotide-long RNA molecules that play a variety of roles in biology.
SiRNAs were first discovered by David Baulcombe's group in Norwich, England, as part of post-transcriptional gene silencing (PTGS) in plants[1].
SiRNAs can also be exogenously (artificially) introduced into cells by various transfection methods to bring about the specific knockdown of a gene of interest.
  More results at FactBites »


 

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