Sigil was originally published by CrossGeneration Comics in July 2000 and lasted until December of 2003 at issue forty-two. Sigil was one of the publishers first four titles (the others are Mystic, Scion, and Meridian), a sci-fi space opera, originally created by Mark Alessi and Gina Villa.

Sigil starred Samandahl Rey, a former solider for the Planetary Union. Years ago, he and his good friend Roiya Sintor were laid off from the army thanks to cut-backs, and had since became mercenaries. The pair were "vactioning" on the pleasure world of Tanipal when the series began. While on Tanipal, Sam and Roiya meet a mysterious orange eyed-man named JeMerik and an attractive beauty called Zaniatti. It was just as the four had gathered that a Saurian assissin squad dropped in looking for Sam. During his time as a solider, Sam had made an enemy of Tchulsarud, the youngest Saurian prince. "Loser", as Sam called him, had a blood right to hunt down and kill Sam, by any means necessary, and was willing to try. It was during the attack that three important things happened. The first was the odd group meeting up. The second was Sam's branding. During the fight, Sam was tackled by an odd Saurian with glowing orange eyes. The Saurian cryptically said to Sam "You shall find them, gather them, and lead them" while branding him with an odd red and yellow mark - the sigil. It then dissapeared into thin air. While Sam was distracted, one of the attacking Saurians ran Roiya through, fatally injuring her. The four retreated back to Sam's ship, the Bitterluck, where they attempted to save Roiya. However, to Sam's eyes, she died. And in a fit of rage he activated his sigil, destroying a large part of Tanipal in the process.

The original creative team consisted of Barbara Kesel, the Lai Brothers, and Wil Quintana, although over the years it changed several times. Penciller Kevin Sharpe got his start on Sigil, followed by Scot Eaton and Dale Eaglesham. After Barbara Kesel stepped down on the writing chores, Mark Waid and Chuck Dixon followed up, adding more action and higher body counts.