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Encyclopedia > Signaling molecule

Nitric oxide is a quite salient signaling molecule, instrumental in both learning and memory. The chemical compound nitric oxide is a gas with chemical formula NO. It is an important signaling molecule in the body of mammals including humans, one of the few gaseous signaling molecules known. ...


Research has shown, quite extensively, that NO or nitric oxide is involved in the formation of learning in rodents. Neurobiologists, internationally, are enthralled with the potential benefits of this molecule.


As well, Nitric oxide, also once known as EDRF, may have a possible role in the type of memory which subserves object recognition.


This molecule is derived from the vascular endothelium, and since its is a gaseous molecule, it diffuses across the membrane and impacts the tonicity of the perivascular smooth muscle. It helps the muscle around the blood vessel, to relax. This is why this paradigm is involved in the action of sildenafil citrate (Viagra) Vascular is an adjective for the word vessel and refers to tube-like structures. ... The endothelium is the layer of thin, flat cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. ... It has been suggested that Net flux be merged into this article or section. ... The elastic tension of living muscles, arteries, etc. ... Sildenafil citrate, sold under the name Viagra, is a drug used to treat male erectile dysfunction (impotence), developed by the pharmaceutical company Pfizer. ... Sildenafil citrate, sold under the name Viagra, is a drug used to treat male erectile dysfunction (impotence), developed by the pharmaceutical company Pfizer. ...


Studies were done in the Netherlands, by researchers and results should be of interest to those individuals concerned with aging, and the biology of longevity, and staying health.


You can learn more about nitric oxide chemistry, through searching either a medical database or specifically for nitricoxidechemistry.


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Notch signaling molecule important in type 2 immunity (1118 words)
Using mice in which Notch signaling could be induced to turn off in mature T cells, the researchers showed that Notch signaling is an important determinant of whether an organism can mount an effective Th2 response.
The mice lacking Notch signaling were unable to mount a protective Th2 cell response against infection by the gastrointestinal parasitic worm Trichuris muris.
Helper T cells fight many types of infectious diseases and are also the cells that regulate tolerance to self and the molecules that cause the pathogenesis of such inflammatory diseases as arthritis, inflammatory bowel disease, and asthma.
Key Signaling Molecule In The Brain That Appears To Trigger The Brain To "learn" A Craving (694 words)
Researchers have identified a key signaling molecule in the brain that appears to trigger the brain to "learn" a craving for cocaine.
Specifically, they found in their studies with rats that orexin A induces an adaptation that is necessary for the development of behaviors associated with drug-craving in human addicts.
Bonci and his colleagues based their experiments on past studies by other researchers showing that orexins are important regulatory peptides released by a brain center called the lateral hypothalamus.
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