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Encyclopedia > Sodium picosulfate
Sodium picosulfate
Systematic (IUPAC) name
disodium 2-[bis(4-sulfonatooxyphenyl)methyl]pyridine
Identifiers
CAS number 10040-45-6
ATC code A06AB08 A06AB58
PubChem 68654
Chemical data
Formula C18H13NNa2O8S2 
Mol. mass 481.409 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links No higher resolution available. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism // A06A Laxatives A06AA Softeners, emollients A06AA01 Liquid paraffin A06AA02 Docusate sodium A06AA51 Liquid paraffin, combinations A06AB Contact laxatives A06AB01 Oxyphenisatine A06AB02 Bisacodyl A06AB03 Dantron A06AB04 Phenolphthalein A06AB05 Castor oil A06AB06 Senna glycosides A06AB07 Cascara A06AB08 Sodium... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism // A06A Laxatives A06AA Softeners, emollients A06AA01 Liquid paraffin A06AA02 Docusate sodium A06AA51 Liquid paraffin, combinations A06AB Contact laxatives A06AB01 Oxyphenisatine A06AB02 Bisacodyl A06AB03 Dantron A06AB04 Phenolphthalein A06AB05 Castor oil A06AB06 Senna glycosides A06AB07 Cascara A06AB08 Sodium... PubChem is a database of chemical molecules. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number sodium, Na, 11 Chemical series alkali metals Group, Period, Block 1, 3, s Appearance silvery white Atomic mass 22. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... General Name, Symbol, Number sulfur, S, 16 Chemical series nonmetals Group, Period, Block 16, 3, p Appearance lemon yellow Standard atomic weight 32. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes Oral

Sodium picosulfate (INN, also known as sodium picosulphate) is a contact laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. It is sold under the trade names Dulcolax, Laxoberal, Picolax, Guttalax and several others. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... A laxative is a preparation used for encouraging defecation, or the expulsion of feces. ... Constipation or irregularity, is a condition of the digestive system where a person (or animal) experiences hard feces that are difficult to eliminate; it may be extremely painful, and in severe cases (fecal impaction) lead to symptoms of bowel obstruction. ... Colonoscopy is the minimally invasive endoscopic examination of the large colon and the distal part of the small bowel with a fiber optic camera on a flexible tube passed through the anus. ... A cardiothoracic surgeon performs a mitral valve replacement at the Fitzsimons Army Medical Center. ...


Side effects

The most common side effects of picosulfate are abdominal cramps and diarrhea. An adverse drug reaction (abbreviated ADR) is a term to describe the unwanted, negative consequences sometimes associated with the use of medications. ...


The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.[1] Electrolyte disturbance refers to an abnormal change in the levels of electrolytes in the body. ... The electrolyte disturbance hyponatremia or hyponatraemia exists in humans when the sodium level in the plasma falls below 135 mmol/l. ... Hypokalemia is a potentially fatal condition in which the body fails to retain sufficient potassium to maintain health. ...


References

  1. ^ ADRAC (February 2002). "Electrolyte disturbances with sodium picosulfate bowel cleansing products". Aust Adv Drug React Bull 21 (1).  Free full text from the Australian Therapeutic Goods Administration

  Results from FactBites:
 
Patent 4948591: Soft capsular preparation of sodium picosulfate (1329 words)
The soft capsular preparation according to claim 1, wherein the ratio of polyethylene glycol/sodium picosulfate is at least 4 parts by weight of polyethylene glycol per 1 part by weight of sodium picosulfate.
The soft capsular preparation according to claim 2, wherein the ratio of polyethylene glycol/sodium picosulfate is 8 to 45 parts by weight of polyethylene glycol per 1 part by weight of sodium picosulfate.
In view of this situation, the present inventors have undertaken extensive studies, and found that a soft capsular preparation of sodium picosulfate which is stable for an extended period of time can be prepared by dissolving sodium picosulfate in polyethylene glycol and encapsulating the solution into a soft capsular film.
971. Sodium sulfate (WHO Food Additives Series 44) (1869 words)
Sodium sulfate was not specifically included in that ADI because no information was available to indicate that it was being manufactured or used as a food-grade material.
When sodium sulfate was included in the treatment, the mean quantity of acetaminophen sulfate excreted in the urine increased but the difference from the treatment without sodium sulfate did not achieve statistical significance.
Sodium sulfate decahydrate and its anhydrous salt are listed in Martindale's Pharmacopoeia, and the laxative use is noted; another medical use recorded is in the treatment of severe hypercalcaemia, in which it is given by slow intravenous administration of a 3.9% aqueous solution.
  More results at FactBites »


 

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