Spencer, Missouri is a small crossroads on former U.S. Highway 66 (now a county road) in eastern Lawrence County about six miles west of Halltown. It started as a post office founded in the late 1870's on Carthage Road, later to become US 66. A store and church were built, but in 1912 the old road became impassable and the town dwindled. When US 66 was established, the town grew again, but the building of nearby Interstate 44 closed down the town to a couple of homes. U.S. Highway 66 or Route 66 was and is the most famous road in the U.S. Highway system and quite possibly the most famous and storied highway in the world. ... Lawrence County is a county located in the state of Missouri. ... Halltown is a village located in Lawrence County, Missouri. ... Carthage is a city located in Jasper County, Missouri. ... Interstate 44 is an interstate highway in the central United States. ...