The Subfornical organ is one of the circumventricular organs of the brain and is involved in thirst-regulation.
It is a small nodule (approx 1mm in humans) situated on the ventral surface of the fornix, at the foramin of Monro.
The subfornical organ is sensitive to increased circulating blood levels of the hormone ADH (Vasopressin) which stimulates the sensation of thirst. Thirst is also stimulated as a result of osmoreceptor activity in the Organum Vasculosm of the Lamina Terminalis. Antidiuretic hormone (ADH), or arginine vasopressin (AVP), is a peptide hormone produced by the hypothalamus, and stored in the posterior part of the pituitary gland. ... An osmoreceptor is a sensory receptor primarily found in the hypothalamus of most homeothermic organisms that detects changes in osmotic pressure. ...
Subfornicalorgan efferents influence the excitability of neurohypophysial and tuberoinfundibular paraventricular nucleus neurons in the rat.
Angiotensin II may mediate excitatory neurotransmission from the subfornicalorgan to the hypothalamic supraoptic nucleus: an anatomical and electrophysiological study in the rat.
Lesion of the subfornicalorgan affects the haemotensive response to centrally administered relaxin in aneaesthetized rats.
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