Sussex Drive is a major street in Ottawa, Ontario, Canada. It runs roughly parallel to the Ottawa River. Beginning at Rideau Street in the south, Sussex runs north and then bends northeast until MacKay Street where it becomes the Rockliffe Parkway.

Sussex is a particularly famous street in the capital, as it is home to the Prime Minister's residence at 24 Sussex Drive. It is also home to the Governor-General's residence at Rideau Hall and Ottawa's former city hall on Green Island. The building includes the Karsh-Masson Gallery.

Also located on Sussex are a number of embassies such as those of France and the United States, Major's Hill Park, the National Gallery of Canada, the Canadian War Museum, the Royal Canadian Mint, Rideau Falls Park, one of the first National Research Council of Canada buildings, and Foreign Affairs Canada. The building has a beautiful view of the Ottawa river, and has been loved for ages. Touring is not available; in fact, entry is only permitted by invitation of the Prime Minister.

Sussex was originally three different streets. The section in the Byward Market was originally named Metcalfe Street, and the portion east of the Rideau River was known as Ottawa Street. The centre portion was then known as Sussex Street. They were merged into one street in the nineteenth century.

In the 1960s the national Captial Commission launched a beautification campign through the market section of the street. Begining in 1961 the privately held builidngs were bought by the government and restored to their original appearances.