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Encyclopedia > T4 phage
Enterobacteria phage T4
Scientific classification
Kingdom: Virus
(unranked) dsDNA viruses
Order: Caudovirales
Family: Myoviridae
Genus: T4-like viruses
Species: Enterobacteria phage T4

Enterobacteria phage T4 is a phage that infects E. coli bacteria.


Its DNA is 169-170 kb long, one of the longest DNAs in phages. The lifecycle (from entering a bacteria to its destruction) takes about 30 minutes (at 37 °C) and contains of:

  • adsorption and penetration (starting immediately)
  • arrest of host gene expression (starting immediately)
  • enzyme synthesis (starting after 5 minutes)
  • DNA replication (starting after 10 minutes)
  • virus formation (starting after 12 minutes)

After the lifecycle is complete the cell bursts open and ejects the newly built viruses into the environment. The host cell is destroyed.


The T4 phage has some unique features, like

  • eukaryote style Introns
  • high speed DNA copying engine with only 1 error in 300 copies
  • special DNA repair mechanisms

  Results from FactBites:
 
Enterobacteria phage T4 - Wikipedia, the free encyclopedia (760 words)
Enterobacteria phage T4 is a phage that infects E.
T4 is also one of the largest phages, at approximately 90 nm wide and 200 nm long (most phages range from 25 to 200 nm in length).
T4 is only capable of undergoing a lytic lifecycle and not the lysogenic life cycle.
Bacteriophage - Wikipedia, the free encyclopedia (1498 words)
Phages are ubiquitous and can be found in all reservoirs populated by bacterial hosts, such as soil or the intestine of animals.
In the case of the T4 phage, the construction of new virus particles is a complex process which requires the assistance of special helper molecules.
Research on phage therapy was largely discontinued in the West, but phage therapy has been used since the 1940s in the former Soviet Union as an alternative to antibiotics for treating bacterial infections.
  More results at FactBites »


 

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