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Tachyphylaxis is a medical term describing a rapidly decreasing response to a drug following administration of the initial doses. Examples of tachyphylaxis are the following :
Nitroglycerine demonstrates tachyphylaxis, requiring drug-free intervals when administered transdermally
Repeated doses of ephedrine may display tachyphylaxis, since it is an indirectly acting sympathomimetic amine which will deplete noradrenaline from the nerve terminal. Thus repeated doses result in less noradrenaline being released than the initial dose.
Nicotine may also show tachyphylaxis over the course of a day, although the mechanism of this action is unclear.
Hydralazine displays tachyphylaxis if given as a monotherapy for antihypertensive treament. It is administered with a beta-blocker with or without a diuretic.
Nitroglycerin (also nitroglycerine, trinitroglycerin, or glyceryl trinitrate) is a chemical compound, a heavy, colorless, poisonous, oily, explosive liquid obtained by nitrating glycerol. ... Ephedrine (EPH) is a sympathomimetic amine similar in structure to the synthetic derivatives amphetamine and methamphetamine. ... Sympathomimetics are a class of drugs whose properties mimic those of a stimulated sympathetic nervous system. ... Not to be confused with Niacin, which is the oxide of Nicotine, and has a very different biological effect. ... Hydralazine hydrochloride (1 -hydrazinophthalazine monohydrochloride; Apresoline®) is a medication used to treat high blood pressure. ... Metoclopramide (INN) (IPA: ) is a potent dopamine receptor antagonist used for its antiemetic and prokinetic properties. ... Dobutamine is a beta adrenergic agonist. ... Beta2-adrenergic receptor agonists are a class of drugs used to treat asthma and other pulmonary disease states. ...
ephedrine Desensitization is a method to reduce or eliminate an organisms negative reaction to a substance or stimulus. ... In physiology, tolerance occurs when an organism builds up a resistance to the effects of a substance after repeated exposure. ... Physical dependence describes increased tolerance of a drug combined with a physical need of the drug to function. ... Mithridates VI of Pontus, (132 BC- 63 BC), called Eupator Dionysius, was the king of Pontus in Asia Minor and one of Romes most formidable and successful enemies. ...
Tachyphylaxis is a medical term describing a rapidly decreasing response to a drug following administration of the initial doses.
Repeated doses of ephedrine may display tachyphylaxis, since it is an indirectly acting sympathomimetic amine which will deplete noradrenaline from the nerve terminal.
Nicotine may also show tachyphylaxis over the course of a day, although the mechanism of this action is unclear.
Absence of tachyphylaxis to octreotide therapy in a patient with a GH-secreting pituitary adenoma (A) and desensitization in a patient with metastatic carcinoid tumor (B).
The induction of tachyphylaxis of responsiveness to SS-agonists
The time-frame of the occurrence of tachyphylaxis in vivo on
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