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Encyclopedia > Telepathine

Harmala, also known at various times as Telepathine and Banisterine, is a blanket term for a group of naturally occurring beta-carbolines including harmine, harmaline, and others. The harmala alkaloids are tryptamines and monoamine oxidase inhibitors. They also act as serotonin antagonists and CNS stimulants. β-Carboline (9H-pyrid-[3,4-b]-indole) is an organic amine that is the prototype of a class of compounds known as β_Carbolines. ... An alkaloid is a nitrogenous organic molecule that has a pharmacological effect on humans and other animals. ... Tryptamine (3-(2-aminoethyl)indole) is a monoamine compound that is widespread in nature. ... Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. ... Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. ... The human central nervous system consists of the brain and spinal cord. ...


Harmala is found most commonly in the seeds of Syrian rue (Peganum harmala), where it occurs in concentrations of up to 3%, and also Banisteriopsis caapi, where it occurs in lower concentrations. In Caapi, it is used in combination with a DMT containing admixture to form a South American Entheogen known as Ayahuasca; in high enough doses, it is slightly hallucinogenic on its own. Species Pagnum harmala Syrian Rue (Pagnum harmala) is a member of the Zygophyllaceae family. ... Binomial name Banisteriopsis caapi Banisteriopsis caapi, also known as Ayahuasca, Caapi or Yage, is a South American jungle vine of the family Malpighiaceae. ... Dimethyltryptamine, also known as DMT or N,N-dimethyltryptamine, is a short-acting psychedelic hallucinogenic drug. ... This entry covers entheogens in the strict sense of the word (i. ... The widely used Quechuan name Ayahuasca has two highly interrelated yet distinct meanings and referents: 1) an Amazonian giant vine native to the rainforest, generally Banisteriopsis caapi, and, by extension, 2) pharmacologically complex infusions prepared from it for shamanic, folk-medicinal, and neoreligious purposes. ...


Harmala alkaloids are also found many other plants, such as tobacco and passion flower. Species N. alata N. bigelovil N. debneyi N. excelsior N. exigua N. glauca N. glutinosa N. kawakamii N. knightiana N. longiflora N. sylvestris N. tabacum Ref: ITIS 30562 as of 2002-08-28 Tobacco () is a broad-leafed plant of the nightshade family, indigenous to North and South America, whose... Species Passiflora amalocarpa Passiflora amethystina Passiflora aurantia Passiflora caerulea Passiflora capsularis Passiflora edulis Passiflora foetida Passiflora helleri Passiflora holosericea Passiflora incarnata Passiflora karwinskii Passiflora mucronata Passiflora murucuja Passiflora tenuifila Passiflora tulae Passiflora vitifolia Passiflora yucatanensis Passion flower refers to vines in the genus Passiflora—flowering plants known for their showy...

Contents

Telepathine

Telepathine was originally thought to be the active chemical constituent of Ayahuasca which gave Native users from the Amazon jungle collective contact with and/or visions of jaguars, snakes, and jeweled birds -- not to mention dead ancestors, the ability to see future events, and as the name suggested, telepathic communication among tribal members. It was assumed to be a newly discovered chemical, the active compound of Banisteriopsis caapi; however, it was discovered that Telepathine was already known more widely as Harmine. The widely used Quechuan name Ayahuasca has two highly interrelated yet distinct meanings and referents: 1) an Amazonian giant vine native to the rainforest, generally Banisteriopsis caapi, and, by extension, 2) pharmacologically complex infusions prepared from it for shamanic, folk-medicinal, and neoreligious purposes. ... Telepathy from the Greek τηλε, tele, distant, and πάθεια, patheia, feeling, is the supposed ability to communicate information from one mind to another, and is one form of extra-sensory perception or anomalous cognition. ... Binomial name Banisteriopsis caapi Banisteriopsis caapi, also known as Ayahuasca, Caapi or Yage, is a South American jungle vine of the family Malpighiaceae. ...


Uses

As mentioned above, harmala is used as an MAOI (MonoAmine Oxidase Inhibitor) to facilitate the oral ingestion of DMT and other tryptamines; it is also hallucinogenic on its own. In high doses, it acts a sedative. Harmine has been used effectively to alleviate the tremors that come with Parkinson's disease. It is unclear whether harmala can actually facilitate the telepathy it was once named for. Parkinsons disease (PD; paralysis agitans) is a neurodegenerative disease of the substantia nigra (an area in the basal ganglia of the brain). ...


Chemical Forms

  • Harmine: C13H12N2O
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
  • Harmaline: C13H14N2O
4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole
  • Tetrahydroharmine: C13H16N2O4P
7-Methoxy-1,2,3,4-Tetrahydro-Harmine
  • Harmine acid: methylester:
Methyl-7-methoxy-b-carboline-1-carboxylate
  • Harmilinic acid:
7-methoxy-3,4-dihydro-b-carboline1-carboxylic acid
  • Harmanamide:
1-carbamoyl-7-methoxy-b-carboline
  • Acethylnorharnine:
1-acethyl-7-methoxy-b-carboline

See also


  Results from FactBites:
 
Harmala alkaloid - Wikipedia, the free encyclopedia (552 words)
The Harmala alkaloid "Harmine", also known as Telepathine and Banisterine, is a naturally occurring beta-carboline alkaloid that is structurally related to harmaline.
Telepathine was originally thought to be the active chemical constituent of Banisteriopsis caapi, a key plant ingredient in the preparation of Ayahuasca; a sacremental beverage from the Amazon.
This isolated chemical was so named because of the reported effects of Ayahuasca among the indigenous users, including: collective contact with and/or visions of jaguars, snakes, and jeweled birds, and ancestral spirits; the ability to see future events; and as the name suggests, telepathic communication among tribal members.
  More results at FactBites »


 

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