Born in Charles Town, Virginia (now West Virginia), Worthington moved to Ross County, Ohio in 1796. He served in the Territorial House of Representatives from 1799-1803 and served as a delegate to the State Constitutional Convention in 1803. Worthington was elected one of Ohio's first Senators in 1803, serving until 1807. He was returned to the Senate in December1810 upon the resignation of Return J. Meigs, Jr. and served until December 1814, when he resigned after winning election to the governorship. He won re-election two years later, moving the state capital from Chillicothe to Columbus. Worthington did not seek re-election in 1818. He narrowly lost a bid for a third partial term in the Senate in 1821, losing to the incumbent governor, Ethan Allen Brown, instead returning to the Ohio House of Representatives.
ThomasWorthington (1826 – 1909) was an eminent 19th century English architect, particularly associated with public buildings in his native Manchester.
Worthington was the fourth of six sons of a Salford Unitarian cotton merchant.
Worthington was strongly influenced by his Unitarian upbringing, becoming committed to social reform and improvement, and joining numerous learned societies, including the Manchester Literary and Philosophical Society, the Portico Library and the Royal Manchester Institution.
Worthington himself had in 1596 addressed a memorial to the cardinal protector on the state of the Roman College, in which he calls attention to the decline of Douai, which he ascribes to the innovations of Dr. Barrett.
Worthington was granted an annual pension of 200 crowns, and appointed an Apostolic notary with a place on the Congregation of the Index.
Thomas was retaken with his uncle at Islington, and remained a prisoner in the Gatehouse for upwards of two and a half years.